2. Autophagy Apoptosis
  3. Autophagy Apoptosis
  4. Erythrabyssin II

Erythrabyssin II (EL-19) is a potent late-stage autophagy inhibitor that blocks the fusion of autophagosome and lysosome. Erythrabyssin II leads to the accumulation of autophagic substrates and does not impair lysosomal pH or lysosomal enzyme activity. Erythrabyssin II suppresses ovarian cancer organoid activity and induces apoptosis. Erythrabyssin II can be used for the study of ovarian cancer.

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Erythrabyssin II Chemical Structure

Erythrabyssin II Chemical Structure

CAS No. : 77263-06-0

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Erythrabyssin II Related Antibodies

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Description

Erythrabyssin II (EL-19) is a potent late-stage autophagy inhibitor that blocks the fusion of autophagosome and lysosome. Erythrabyssin II leads to the accumulation of autophagic substrates and does not impair lysosomal pH or lysosomal enzyme activity. Erythrabyssin II suppresses ovarian cancer organoid activity and induces apoptosis. Erythrabyssin II can be used for the study of ovarian cancer[1].

Cellular Effect
Cell Line Type Value Description References
ARPE-19 GI50
> 100 μM
Compound: 2
Cytotoxicity against human ARPE-19 cells assessed as cell growth inhibition incubated for 44 hrs by AlamarBlue reagent based fluorescence assay
Cytotoxicity against human ARPE-19 cells assessed as cell growth inhibition incubated for 44 hrs by AlamarBlue reagent based fluorescence assay
[PMID: 36938984]
Breast carcinoma cell IC50
2.9 μg/mL
Compound: 53
Cytotoxicity against human Breast carcinoma cell assessed as reduction in cell viability by colorimetric assay
Cytotoxicity against human Breast carcinoma cell assessed as reduction in cell viability by colorimetric assay
[PMID: 28189086]
KB IC50
5.1 μg/mL
Compound: 53
Cytotoxicity against human KB cells assessed as reduction in cell viability by colorimetric assay
Cytotoxicity against human KB cells assessed as reduction in cell viability by colorimetric assay
[PMID: 28189086]
MCF7 IC50
> 30 μM
Compound: 14
Cytotoxicity against human MCF7 cells by WST-1 assay
Cytotoxicity against human MCF7 cells by WST-1 assay
[PMID: 19836230]
MCF7 IC50
> 30 μM
Compound: 14
Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay
Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay
[PMID: 19836230]
MCF7 IC50
> 30 μM
Compound: 14
Cytotoxicity against human adriamycin- resistant MCF7 cells by WST-1 assay
Cytotoxicity against human adriamycin- resistant MCF7 cells by WST-1 assay
[PMID: 19836230]
MDA-MB-231 IC50
> 30 μM
Compound: 14
Cytotoxicity against human MDA-MB-231 cells by WST-1 assay
Cytotoxicity against human MDA-MB-231 cells by WST-1 assay
[PMID: 19836230]
Molecular Weight

392.49

Formula

C25H28O4
CAS No.
SMILES

OC1=C(C/C=C(C)\C)C=C2[C@@](OC3=C(C/C=C(C)\C)C(O)=CC=C34)([H])[C@@]4([H])COC2=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Erythrabyssin II Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Erythrabyssin II77263-06-0AutophagyApoptosislate-stage autophagy inhibitorovarian cancerapoptosisInhibitorinhibitorinhibit

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