2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage
  3. FXR PPAR
  4. dual FXR/PPARδ agonist-2

dual FXR/PPARδ agonist-2 is a FXR/PPARδ dual agonist through hybridation of FXR agonist GW-4064 and PPARδ agonist GW-0742.dual FXR/PPARδ agonist-2 displays potent dual-target activities with a FXR agonistic EC50 of 12.28 nM and 69 % PPARδ activation at 100 nM. dual FXR/PPARδ agonist-2 shows anti-fibrotic effects in pulmonary fibrosis mouse model.

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dual FXR/PPARδ agonist-2

dual FXR/PPARδ agonist-2 Chemical Structure

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dual FXR/PPARδ agonist-2 Related Antibodies

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Description

dual FXR/PPARδ agonist-2 is a FXR/PPARδ dual agonist through hybridation of FXR agonist GW-4064 and PPARδ agonist GW-0742.dual FXR/PPARδ agonist-2 displays potent dual-target activities with a FXR agonistic EC50 of 12.28 nM and 69 % PPARδ activation at 100 nM. dual FXR/PPARδ agonist-2 shows anti-fibrotic effects in pulmonary fibrosis mouse model[1].

IC50 & Target[1]

FXR

12.28 nM (EC50)

In Vivo

dual FXR/PPARδ agonist-2 (Compound 10g) (40 mg/kg, i.p., daily for 21 days) significantly attenuates collagen deposition and reduces the expression of α-SMA in Bleomycin (BLM) (HY-108345)-induced pulmonary fibrosis mice models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Bleomycin (BLM) (HY-108345)-induced pulmonary fibrosis mice models[1]
Dosage: 40 mg/kg
Administration: Intraperitoneally injection, daily for 21 days
Result: Reduced lesion density (fewer and smaller foci) and diminished septal thickening.
Suppressed collagen accumulation and fibrotic progression.
Attenuated α-SMA deposition.
Molecular Weight

519.55

Formula

C26H29N7O5
SMILES

CC1=NOC(C2=CC=C(C=C2)CN(C)C)=C1COC(N3CCN(CC3)C4=NN5C(C(O)=O)=CN=C5C=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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dual FXR/PPARδ agonist-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

dual FXR/PPARδ agonist-2FXRPPARNR1H4Peroxisome proliferator-activated receptorsPulmonary fibrosisBleomycinCollagenα-SMAInhibitorinhibitorinhibit

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