2. GPCR/G Protein
  3. Chemerin Receptor
  4. VU0514009

VU0514009 is a competitive chemokine-like receptor 1 (CMKLR1) antagonist (EC50=2 nM). VU0514009 prevents chemerin-9-induced arrestin recruitment and receptor internalization, significantly reducing Ca2+ flux response in HEK293 cells. VU0514009 is promising for research of inflammatory diseases and metabolic syndrome.

For research use only. We do not sell to patients.

VU0514009

VU0514009 Chemical Structure

CAS No. : 932973-77-8

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VU0514009 Related Antibodies

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ChemR23/CMKLR1

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Description

VU0514009 is a competitive chemokine-like receptor 1 (CMKLR1) antagonist (EC50=2 nM). VU0514009 prevents chemerin-9-induced arrestin recruitment and receptor internalization, significantly reducing Ca2+ flux response in HEK293 cells. VU0514009 is promising for research of inflammatory diseases and metabolic syndrome[1].

IC50 & Target

ChemR23/CMKLR1

2 nM (EC50)

Molecular Weight

493.98

Formula

C21H20ClN3O5S2
CAS No.
SMILES

O=C1C(S(C2=CC=C(C(Cl)=C2)C)(=O)=O)=CNC(SCC(NC3=CC(C)=CC=C3OC)=O)=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VU0514009 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU0514009932973-77-8VU 0514009VU-0514009Chemerin ReceptorCMKLR1arrestin recruitmentreceptor internalizationinflammatory diseasesInhibitorinhibitorinhibit

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