2. Neuronal Signaling
  3. α-synuclein
  4. Cinpanemab

Cinpanemab  (Synonyms: BIIB054; Anti-Alpha-synuclein Reference Antibody (cinpanemab))

Cat. No.: HY-P99356 Purity: ≥99.0%
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Cinpanemab (BIIB054) is a human-derived monoclonal antibody that binds to α-synuclein. Cinpanemab can be used for the research of Parkinson's disease.

For research use only. We do not sell to patients.

CAS No. : 2094516-02-4

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Description

Cinpanemab (BIIB054) is a human-derived monoclonal antibody that binds to α-synuclein. Cinpanemab can be used for the research of Parkinson's disease[1][2].

Isotype

Human IgG1 lambda1
Recommend Isotype Controls
Species

Humanized
IC50 & Target

α-synuclein

 

In Vitro

Cinpanemab is highly selective for aggregated forms of α-syn with at least an 800-fold higher apparent affinity for fibrillar versus monomeric recombinant α-syn and a strong preference for human PD brain tissue[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cinpanemab Related Antibodies
In Vivo

Cinpanemab (30 mg/kg; i.p.) improves PD-like phenotypes in α-syn PFF inoculation mouse models [2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6JRccHsd WT mice, transgenic M83 mice expressing human α-syn A53T, and transgenic bacterial artificial chromosome mice expressing human α-syn A53T were anesthetized and stereotaxically injected with α-syn preformed fibrils (PFFs) into the right forebrain[2]
Dosage: 30 mg/kg
Administration: Intraperitoneal (i.p.) injections 2-3 times prior to α-syn PFF injection and weekly post-injection until time of sacrifice
Result: Attenuated the spreading of α-syn pathology, rescued motor impairments, and reduced the loss of dopamine transporter density in dopaminergic terminals in striatum.
Clinical Trial
Molecular Weight

146980.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Cinpanemab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda
Biological Activity
  • Immobilized Human SNCA Protein, Human (HY-P70577) can bind Cinpanemab. The EC50 for this effect is 10.13 ng/mL.
Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (231 KB) SDS-PAGE (69 KB) SEC-HPLC (133 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Cinpanemab Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cinpanemab2094516-02-4BIIB054Anti-Alpha-synuclein Reference Antibody (cinpanemab)BIIB 054BIIB-054α-synucleinα-SynParkinson's diseaseInhibitorinhibitorinhibit

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