2. NF-κB Immunology/Inflammation
  3. Interleukin Related NF-κB
  4. Breviscapine

Breviscapine  (Synonyms: Breviscapinun)

Cat. No.: HY-107802 Purity: 95.59%
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Breviscapine is a crude flavonoid extract of Breviscapine, which is more than 85% of the active ingredient, Breviscapine. Breviscapine has a wide range of cardiovascular pharmacological activities, such as increasing blood flow, improving microcirculation, dilating blood vessels, reducing blood viscosity, promoting fibrinolysis, inhibiting platelet aggregation and thrombosis. Breviscapine has been used in the study of cerebral infarction and its sequelae, cerebral thrombosis, coronary heart disease and angina pectoris.

For research use only. We do not sell to patients.

Breviscapine Chemical Structure

Breviscapine Chemical Structure

CAS No. : 116122-36-2

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Customer Review

Based on 1 publication(s) in Google Scholar

Breviscapine Related Antibodies

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Breviscapine is a crude flavonoid extract of Breviscapine, which is more than 85% of the active ingredient, Breviscapine. Breviscapine has a wide range of cardiovascular pharmacological activities, such as increasing blood flow, improving microcirculation, dilating blood vessels, reducing blood viscosity, promoting fibrinolysis, inhibiting platelet aggregation and thrombosis. Breviscapine has been used in the study of cerebral infarction and its sequelae, cerebral thrombosis, coronary heart disease and angina pectoris[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 50 μM
Compound: 1
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 30243153]
Bel-7402 IC50
> 50 μM
Compound: 1
Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay
Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay
[PMID: 30243153]
HCT-116 IC50
77 μM
Compound: Scutellarin
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 28458133]
HepG2 IC50
56.09 μM
Compound: Scutellarin
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 28458133]
L02 IC50
> 100 μM
Compound: Scutellarin
Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay
Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay
[PMID: 28458133]
L02 IC50
> 50 μM
Compound: 1
Cytotoxicity against human LO2 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human LO2 cells assessed as decrease in cell viability after 72 hrs by MTT assay
[PMID: 30243153]
MCF7 IC50
> 100 μM
Compound: Scutellarin
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 28458133]
MCF7 IC50
> 50 μM
Compound: 1
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 30243153]
PC-3 IC50
72.9 μM
Compound: Scutellarin
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
[PMID: 28458133]
Clinical Trial
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C=C(C1=CC=C(O)C=C1)OC2=CC(O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3C(O)=O)=C4O)C2=C4O.O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O5)O)O)[C@@H]5OC6=CC(O)=C7C(C=C(C8=CC=C(O)C=C8)OC7=C6)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

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Purity & Documentation
References
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Breviscapine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Breviscapine116122-36-2BreviscapinunInterleukin RelatedNF-κBILNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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