2. Antibody-drug Conjugate/ADC Related Apoptosis
  3. ADC Antibody TNF Receptor
  4. Belantamab

Belantamab  (Synonyms: GSK2857914)

Cat. No.: HY-P9980 Purity: 99.90%
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COA
Technical Support

Belantamab (GSK2857916) is a humanized IgG1 anti-BCMA/TNFRSF17 monoclonal antibody. Belantamab is linked to MMAF (HY-15579) through a non-cleavable ADC linker to synthesize the antibody-active molecule conjugate (ADC) Belantamab mafodotin (HY-P3239). After binding to BCMA on the surface of tumor cells, Belantamab mafodotin enters the cell through receptor-mediated endocytosis. After entering the cell, Belantamab mafodotin releases MMAF, blocks cell division by inhibiting tubulin polymerization, arrests the cell cycle and induces cell apoptosis. Belantamab can be used for the study of multiple myeloma, especially relapsed/refractory multiple myeloma.

For research use only. We do not sell to patients.

CAS No. : 2061894-48-0

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Based on 1 publication(s) in Google Scholar

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Belantamab Related Antibodies

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View All TNF Receptor Isoform Specific Products:

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Belantamab (GSK2857916) is a humanized IgG1 anti-BCMA/TNFRSF17 monoclonal antibody. Belantamab is linked to MMAF (HY-15579) through a non-cleavable ADC linker to synthesize the antibody-active molecule conjugate (ADC) Belantamab mafodotin (HY-P3239). After binding to BCMA on the surface of tumor cells, Belantamab mafodotin enters the cell through receptor-mediated endocytosis. After entering the cell, Belantamab mafodotin releases MMAF, blocks cell division by inhibiting tubulin polymerization, arrests the cell cycle and induces cell apoptosis. Belantamab can be used for the study of multiple myeloma, especially relapsed/refractory multiple myeloma[1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
Clinical Trial
Molecular Weight

146060.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Belantamab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized BCMA/TNFRSF17 Protein, Human can bind Belantamab. The EC50 for this effect is 8.0 ng/mL.
  • Loaded Belantamab on AHC2 biosensor, can bind BCMA/TNFRSF17 Protein, Human (HEK293, His, HY-P72847) with an affinity constant of 3.934E-10 M as determined in BLI assay.
Purity & Documentation

Purity: 99.90%

SDS (251 KB)

COA (231 KB) SDS-PAGE (128 KB) SEC-HPLC (79 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Belantamab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Belantamab2061894-48-0GSK2857914GSK 2857914GSK-2857914ADC AntibodyTNF ReceptorTumor Necrosis Factor ReceptorTNFRhumanised IgG1monoclonal antibodyTNFRSF17Inhibitorinhibitorinhibit

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