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  4. UQCRC1 Antibody (YA3954)

UQCRC1 Antibody (YA3954)

Cat. No.: HY-P84257
User Guide for Antibodies Technical Support

UQCRC1 Antibody (YA3954) is a mouse-derived and non-conjugated IgG1 antibody, targeting to UQCRC1. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human, mouse, rat.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
Synthetic products have potential research and development risk.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

UQCRC1 Antibody (YA3954) is a mouse-derived and non-conjugated IgG1 antibody, targeting to UQCRC1. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human, mouse, rat.

Background

UQCRC1 is a component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain, driving oxidative phosphorylation. The respiratory chain includes three multisubunit complexes: succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), and cytochrome c oxidase (complex IV, CIV), which work together to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient across the inner membrane that powers transmembrane transport and ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, coupling this redox reaction to proton translocation across the mitochondrial inner membrane, with protons carried as hydrogens on the quinol. In the Q cycle, two protons are consumed from the matrix, four protons are released into the intermembrane space, and two electrons are transferred to cytochrome c (by similarity). The two core subunits, UQCRC1/QCR1 and UQCRC2/QCR2, are homologous to the mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP, respectively, and appear to retain MPP processing properties (by similarity). UQCRC1 may be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). It also seems to play a critical role in maintaining proper mitochondrial function in nigral dopaminergic neurons (PubMed:33141179).

Gene ID
SwissProt ID
Synonyms
QCR1; UQCR1; D3S3191
Molecular Weight

Predicted band size: 53 kDa; Observed band size: 53 kDa

Purity

affinity purified.

Conjugation

Non-conjugated

Product Categories

Primary Antibody; Mouse Monoclonal Antibody

Host

Mouse

Reactivity

Human, Mouse, Rat

Dilution Ratio

WB: 1/500-1/2000; IHC: 1/200-1/1000; IF: 1/50-1/200; FC: 1/200-1/400; ELISA: 1/10000

Application

WB, IHC-P, ICC/IF, FC, ELISA

Appearance

Liquid

Formulation

Supplied in PBS with 0.05% sodium azide

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Isotype

IgG1

Immunogen

Purified recombinant fragment of human UQCRC1 (AA: 60-227) expressed in E. Coli.

Documentation

UQCRC1 Antibody (YA3954) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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UQCRC1 Antibody (YA3954)
Cat. No.:
HY-P84257
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