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  4. Toll-Like Receptor 2 Antibody (YA1932)

Toll-Like Receptor 2 Antibody (YA1932)

Cat. No.: HY-P82187
User Guide for Antibodies Technical Support

Toll-Like Receptor 2 Antibody (YA1932) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1932), targeting Toll-Like Receptor 2, with a predicted molecular weight of 89 kDa (observed band size: 89 kDa). Toll-Like Receptor 2 Antibody (YA1932) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in mouse background.

For research use only. We do not sell to patients.

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10 μL In-stock
50 μL In-stock
100 μL In-stock
250 μL   Get quote  

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

Toll-Like Receptor 2 Antibody (YA1932) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1932), targeting Toll-Like Receptor 2, with a predicted molecular weight of 89 kDa (observed band size: 89 kDa). Toll-Like Receptor 2 Antibody (YA1932) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in mouse background.

Background

TLR2 protein collaborates with LY96 to orchestrate the innate immune response against bacterial lipoproteins and various microbial cell wall components. Additionally, TLR2 forms functional complexes with either TLR1 or TLR6 to recognize bacterial lipopeptides. Through the signaling pathways involving MYD88 and TRAF6, TLR2 activation leads to NF-kappa-B activation, cytokine secretion, and the initiation of inflammatory responses. The receptor plays a pivotal role in recognizing specific ligands, such as mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2) and B.burgdorferi outer surface protein A lipoprotein (OspA-L), often in cooperation with TLR6. TLR2 engages in complex interactions with other receptors, including CD14 and CD36, to form activation clusters that trigger signaling events at the cell surface before being directed to the Golgi in a lipid-raft dependent pathway. Furthermore, TLR2 is crucial for the normal uptake of M.tuberculosis, and its interactions extend to various regulatory proteins such as MYD88, TICAM1, and TIRAP.

Gene ID
SwissProt ID
Synonyms
Toll-Like Receptor 2; TLR2; CD282; TIL4; Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4
Molecular Weight

Predicted band size: 89 kDa; Observed band size: 89 kDa

Purity

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

RRID
Research Field

Immunology

Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Clonality

Recombinant, Monoclonal

Host

Rabbit

Reactivity

Mouse

Dilution Ratio

WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200

Application

WB, IHC-F, IHC-P, ICC/IF

Appearance

Liquid

Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Isotype

IgG

Sensitivity

Endogenous

Immunogen

Recombinant protein of mouse TLR2

Database

Entrez Gene: 24088 Mouse

SwissProt: Q9QUN7 Mouse

Documentation

Toll-Like Receptor 2 Antibody (YA1932) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Toll-Like Receptor 2 Antibody (YA1932)
Cat. No.:
HY-P82187
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