TGF β Antibody (YA5387)

TGF β Antibody (YA5387) is a mouse-derived and non-conjugated monoclonal antibody, targeting to TGF-β. It can be applicated for IHC-P, WB assays, in the background of human, mouse, rat.

TGF β (Transforming growth factor beta-1 proprotein) is the precursor of Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, forming the regulatory and active subunits of TGF-beta-1, respectively. It maintains TGF-beta-1 in a latent state via non-covalent interaction with milieu molecules (e.g., LTBP1, LRRC32/GARP, LRRC33/NRROS) (By similarity). Integrins (ITGAV:ITGB6 or ITGAV:ITGB8) distort LAP to release active TGF-beta-1, which then signals through TGFBR1/TGFBR2 receptors. This multifunctional protein regulates cell growth/differentiation, immunity, bone remodeling (By similarity), and exhibits concentration-dependent roles in T-cell differentiation (promoting Treg at high levels or Th17 with IL-6/IL-21 at low levels) (By similarity). It also mediates SMAD2/3 phosphorylation, CREB3L1-activated collagen production, and epithelial-mesenchymal transition (EMT).

P01137

Observed band size: 52 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

IHC1:50-200; WB: 1:1000-2000

IHC-P, WB

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Synthesized peptide derived from human TGF β1 Polyclonal