Tec Antibody (YA5078)

Tec Antibody (YA5078) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Tec. It can be applicated for WB, ELISA assays, in the background of human.

TEC protein, a non-receptor tyrosine kinase, serves as a versatile signal transducer in various cellular processes. Crucial in adaptive immunity, TEC regulates T-cell development, function, and differentiation, impacting IL2 gene induction and CD28 signaling. It collaborates with ITK and BTK in T-cell and B-cell responses, respectively, influencing BCR signaling and cytokine production in mast cells. Additionally, TEC plays a role in myeloid cell growth and differentiation through CSF3 activation, participates in platelet signaling, and cooperates with JAK2 in FOS transcription activation. Notably, TEC is implicated in hepatocyte proliferation, liver regeneration, and regulates FGF2 secretion through unconventional pathways. Its involvement in G protein-coupled receptor and integrin-mediated signaling in platelets, along with a potential role in osteoclast differentiation, underscores the multifaceted contributions of TEC to diverse cellular mechanisms.

P42680

Predicted band size: 74 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of Tec expressed in E. Coli.