SLUG Antibody (YA5060)

SLUG Antibody (YA5060) is a mouse-derived and non-conjugated monoclonal antibody, targeting to SLUG. It can be applicated for WB, ELISA assays, in the background of human.

SLUG is a transcriptional repressor that modulates both activator-dependent and basal transcription. It is involved in the generation and migration of neural crest cells and plays a role in RAF1-induced transcriptional repression of the TJ protein occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (by similar). In breast cells, SLUG represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1. In epidermal keratinocytes, SLUG binds to the E-box in the ITGA3 promoter and represses its transcription, while also regulating ITGB1 and ITGB4 expression, cell adhesion, and proliferation. In hepatocytes, SLUG binds to the E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT). Additionally, SLUG represses E-Cadherin/CDH1 transcription via E-box elements and is involved in osteoblast maturation. It binds to RUNX2 and SOC9 promoters, potentially acting as a positive and negative transcription regulator, respectively, in osteoblasts. In mesenchymal stem cells and osteoblasts, SLUG binds to the CXCL12 promoter via E-box regions. SLUG plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.

O43623

Predicted band size: 30 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human SLUG expressed in E. Coli.