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  4. SENP2 Antibody (YA5505)

SENP2 Antibody (YA5505)

Cat. No.: HY-P85813
User Guide for Antibodies Technical Support

SENP2 Antibody (YA5505) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SENP2. It can be applicated for WB, ICC/IF, ELISA assays, in the background of human.

For research use only. We do not sell to patients.

Size Stock
50 μL   Get quote  
100 μL   Get quote  

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

SENP2 Antibody (YA5505) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SENP2. It can be applicated for WB, ICC/IF, ELISA assays, in the background of human.

Background

SENP2 protein plays a pivotal role in the SUMO pathway, exerting dual functions crucial for the maturation and deconjugation of small ubiquitin-like modifiers (SUMOs). Firstly, it hydrolyzes an alpha-linked peptide bond at the C-terminal end of SUMO propeptides (SUMO1, SUMO2, and SUMO3), facilitating their conversion into mature forms. Secondly, SENP2 contributes to the deconjugation process by cleaving the epsilon-linked peptide bond between the C-terminal glycine of mature SUMO and the lysine epsilon-amino group of target proteins. This dual enzymatic activity enables SENP2 to finely regulate SUMOylation dynamics and impact various cellular processes. Beyond its canonical functions, SENP2 has been implicated in modulating the Wnt pathway, influencing CTNNB1 levels, and actively participating in adipogenesis by desumoylating and stabilizing CEBPB. Additionally, SENP2 emerges as a key player in antiviral responses, contributing to the regulation of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection. The interactions of SENP2 with SUMO isoforms, as well as its binding to proteins like NUP153 and MTA1, further underscore its intricate involvement in cellular processes and signaling pathways.

Gene ID
SwissProt ID
Synonyms
Sentrin-specific protease 2; Axam2; SMT3-specific isopeptidase 2; Smt3ip2; Sentrin/SUMO-specific protease SENP2;
Molecular Weight

Predicted band size: 68 kDa; Observed band size: 65 kDa

Purity

Protein G

Conjugation

Non-conjugated

Modification

Unmodified

Product Categories

Primary Antibody; Mouse Monoclonal Antibody

Clonality

Monoclonal

Host

Mouse

Reactivity

Human

Dilution Ratio

WB: 1:500-2000; ICC/IF: 1:100-500; ELISA: 1:1000-5000

Application

WB, ICC/IF, ELISA

Appearance

Liquid

Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Isotype

IgG1

Immunogen

Synthesized peptide derived from human SENP2 AA range: 430-526

Documentation

SENP2 Antibody (YA5505) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
SENP2 Antibody (YA5505)
Cat. No.:
HY-P85813
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