RbBP5 Antibody (YA5309)

RbBP5 Antibody (YA5309) is a mouse-derived and non-conjugated monoclonal antibody, targeting to RBBP5. It can be applicated for WB, ICC/IF assays, in the background of human, mouse, rat.

RbBP5 plays a crucial role in embryonic stem (ES) cells, particularly in neural lineage differentiation potential, by regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including those mediated by retinoic acid (By similarity). It does not affect ES cell self-renewal (By similarity). As a component or associated component of certain histone methyltransferase complexes, RbBP5 regulates transcription through recruitment of these complexes to gene promoters. As part of the MLL1/MLL complex, it is involved in mono-, di-, and trimethylation at 'Lys-4' of histone H3, which represents a specific tag for epigenetic transcriptional activation. In association with ASH2L and WDR5, RbBP5 stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A, and SETD1B.

Q15291

Observed band size: 70 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

WB: 1:1000; ICC: 1:100; ICC/IF: 1:50-200

WB, ICC/IF

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human RBBP5 protein fragments expressed in E.coli.