PKC delta Antibody (YA6020)

PKC delta Antibody (YA6020) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PKC δ. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

PKC delta, a calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase, plays dual roles in cell death and survival, acting as a pro-apoptotic protein during DNA damage-induced apoptosis and an anti-apoptotic protein during cytokine receptor-initiated cell death. It is implicated in tumor suppression, required for oxygen radical production by NADPH oxidase, and functions as a positive or negative regulator in platelet responses. PKC delta negatively regulates B cell proliferation and plays a crucial role in self-antigen-induced B cell tolerance induction. Under various cellular stresses, PKC delta activates signaling pathways leading to apoptosis, including the activation of death-promoting transcription factor BCLAF1/Btf, modulation of the CHUK/IKKA-p53 axis, and formation of a complex with ABL1. Moreover, it regulates cell cycle progression, mediates the inhibition of cell cycle progression at G1/S phase, and activates the G2/M DNA damage checkpoint. PKC delta is also involved in the control of cell cycle progression and protection of glioma cells from TNFSF10/TRAIL-induced apoptosis. Furthermore, it participates in antifungal immunity and regulates NADPH oxidase activity in neutrophils and eosinophils. PKC delta plays a critical role in platelet functions, acting as a negative regulator of filopodia formation and modulating granule secretion downstream of specific receptors. Its extensive phosphorylation targets, such as MUC1, ELAVL1, mitochondrial phospholipid scramblase 3 (PLSCR3), and SMPD1, underscore its versatility in modulating diverse cellular processes.

Q05655

Predicted band size: 78 kDa; Observed band size: 78 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

IHC: 1:500-1:2000; WB: 1:2000-1:10000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200;

WB, IHC-P, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG