Phospho-c-Met (Tyr1234/1235) Antibody (YA5844)

Phospho-c-Met (Tyr1234/1235) Antibody (YA5844) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-c-Met (Tyr1234/1235).

MET is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor (HGF) ligand. It regulates various physiological processes, including proliferation, scattering, morphogenesis, and survival. Ligand binding induces autophosphorylation of MET on its intracellular domain, creating docking sites for downstream signaling molecules. Upon activation, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3, or the adapter GAB1, leading to the activation of signaling cascades such as RAS-ERK, PI3K-AKT, or PLCgamma-PKC. The RAS-ERK pathway is associated with morphogenetic effects, while PI3K/AKT mediates prosurvival effects. During embryonic development, MET signaling contributes to gastrulation, neuronal precursor migration, angiogenesis, and kidney formation. In skeletal muscle development, it is essential for muscle progenitor cell migration and secondary myoblast proliferation (by similar). In adults, it participates in wound healing, organ regeneration, tissue remodeling, and promotes hematopoietic cell differentiation and proliferation. It may also regulate cortical bone osteogenesis (by similar). Additionally, MET acts as a receptor for Listeria monocytogenes internalin InlB, facilitating pathogen entry into cells.

P08581

Predicted band size: 155 kDa; Observed band size: 155 kDa

Protein A

Non-conjugated

Phosphorylated

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

IHC: 1:200-1:1000; WB: 1:2000-1:10000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200

WB, IHC-P, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG