NGFR p75 Antibody (YA4988)

NGFR p75 Antibody (YA4988) is a mouse-derived and non-conjugated monoclonal antibody, targeting to NGFR p75. It can be applicated for WB, ICC/IF, FC, ELISA assays, in the background of human.

NGFR (Low affinity nerve growth factor receptor), functioning as a low-affinity receptor, exhibits the capability to bind to nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NTF3), and neurotrophin-4 (NTF4). In partnership with SORCS2, NGFR forms a heterodimeric receptor with a high affinity for precursor forms of NGF, BDNF, and NTF3, whereas its affinity for mature NGF and BDNF is considerably lower. Playing a crucial role in the differentiation and survival of specific neuronal populations during development, NGFR can mediate both cell survival and cell death in neural cells. Additionally, NGFR contributes to the regulation of insulin-dependent glucose uptake by influencing the translocation of glucose transporter 4 (GLUT4) to the cell surface in adipocytes and skeletal muscle cells in response to insulin, possibly through the regulation of RAB31 activity. It is essential for the circadian oscillation of clock genes in the brain's suprachiasmatic nucleus and the genes involved in glucose and lipid metabolism in the liver. The NGFR receptor forms homodimers through disulfide linkage and heterodimers with SORCS2. Interactions with various proteins, such as TRIO, RTN4R, TRAFs, SQSTM1, BEX proteins, KIDINS220, NTRK receptors, and others, contribute to its diverse cellular functions.

P08138

Predicted band size: 45 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; ICC/IF: 1:200-1:1000; FC: 1:200-1:400; ELISA: 1:10000

WB, ICC/IF, FC, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human NGFR p75 expressed in E. Coli.