Mouse Anti-Human CD45 Antibody (AF647)(YA3465)

Mouse Anti-Human CD45 Antibody (AF647) is a non-conjugated and Mouse origined monoclonal antibody , targeting to CD45. It can be used for FC assays with AF647, in the background of Human.

Receptor-type tyrosine-protein phosphatase C (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family, also known as CD45, is a transmembrane glycoprotein. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation.
PTPRC contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP.
PTPRC has been shown to be an essential regulator of T- and B-cell antigen receptor signaling as PTPRC positive regulate T-cell coactivation upon binding to DPP4, recruiting and dephosphorylating SKAP1 and FYN. PTPRC also dephosphorylates LYN, and thereby modulates LYN activity.
PTPRC functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. PTPRC also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling.
PTPRC gene has many alternatively spliced transcripts variants, which encode distinct isoforms.

P08575

Predicted band size: 147 kDa; Observed band size: 150 kDa

Protein A affinity purified.

Alexa Fluor® 647

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

FC: 5μL per test for million cells or whole blood in 100 μL volume.

FC

Liquid

Supplied in PBS with 0.05% Proclin300, 1% BSA.

Stored at 2-8°C for 1 year, protect from light, do not freeze.

Shipping with blue ice.

IgG1

A synthesized peptide derived from Human CD45.