MMP13 Antibody (YA6284)

MMP13 Antibody (YA6284) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP13. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse.

MMP-13 (Matrix Metalloproteinase 13) emerges as a pivotal player in extracellular matrix modulation, wielding its influence over various proteins such as fibrillar collagen, fibronectin, TNC, and ACAN. It exhibits notable proficiency in cleaving triple helical collagens, particularly type I, type II, and type III, with the highest activity observed with soluble type II collagen. MMP-13's multifaceted role extends beyond matrix degradation; it may also act on key regulatory proteins, including TGFB1 and CCN2, thereby influencing processes such as wound healing, tissue remodeling, cartilage degradation, and bone development. Its indispensability in embryonic bone development and ossification underscores its significance, while its involvement in fracture healing through endochondral ossification highlights its dynamic contributions to physiological processes. Moreover, MMP-13 plays a role in keratinocyte migration during wound healing and is implicated in cell migration and tumor invasion, reflecting its diverse impact on cellular functions.

P45452

Predicted band size: 60 kDa; Observed band size: 60 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse,

IHC: 1:100-500; WB: 1:500-2000; ICC/IF: 1:200-1000; ELISA: 1:5000-20000; IP: 1:50-200

WB, IHC-P, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG