ApoER2 Antibody (YA4259)

ApoER2 Antibody (YA4259) is a mouse-derived and non-conjugated IgG1 antibody, targeting to LRP8. It can be applicated for FC, ELISA assays, in the background of human.

ApoER2 is a cell surface receptor that binds Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. It transmits the extracellular Reelin signal to intracellular signaling by interacting with DAB1 on its cytoplasmic tail (By similarity). Reelin regulates DAB1 tyrosine phosphorylation and microtubule function in neurons through both VLDL receptor (VLDLR) and ApoER2 (By similarity). ApoER2 exhibits higher affinity for Reelin than VLDLR (By similarity), making it a crucial component of the Reelin pathway governing neuronal layering during embryonic forebrain development (By similarity). It binds endoplasmic reticulum-resident receptor-associated protein (RAP) (By similarity) and β2-glycoprotein I dimers, potentially suppressing platelet aggregation in vasculature. Highly expressed in the epididymis initial segment, it modulates functional expression of sperm maturation proteins clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx) (By similarity). It may function as an endocytic receptor (By similarity) but is dispensable for LRP2-mediated renal SEPP1 uptake (By similarity). Together with apoE, it may indirectly suppress innate immunity by regulating myeloid-derived suppressor cell survival (By similarity). Additionally, it serves as a receptor for Semliki Forest virus (Microbial infection).

Q14114

Predicted band size: 106 kDa; Observed band size: 130/106 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

FC: 1/200-1/400; ELISA: 1/10000

FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human LRP8 (AA: extra 42-182) expressed in E. Coli.