Integrin beta 3 Antibody (YA6104)

Integrin beta 3 Antibody (YA6104) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Integrin β3. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

CD61 is a component of integrin α-V/β-3 (ITGAV:ITGB3) and α-IIb/β-3 (ITGA2B:ITGB3). ITGAV:ITGB3 serves as a receptor for various ligands, including cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin, and von Willebrand factor, and is involved in signaling mediated by CX3CL1, NRG1, FGF1, FGF2, IGF1, IGF2, IL1B, PLA2G2A, FBN1, and CD40LG. ITGA2B:ITGB3 primarily recognizes fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin, and vitronectin, and mediates platelet aggregation upon activation (By similarity). Additionally, ITGAV:ITGB3 plays a role in synaptic transmission and plasticity, regulating serotonin transport and AMPAR endocytosis. It also acts as a receptor for multiple viruses, including Herpes virus 8/HHV-8, Coxsackievirus A9, Hantaan virus, Cytomegalovirus/HHV-5, Human parechovirus 1, and West nile virus. In HIV-1 infection, its interaction with viral Tat protein may promote angiogenesis in Kaposi's sarcoma lesions.

P05106

Predicted band size: 87 kDa; Observed band size: 100 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

IHC: 1:1000-1:4000; WB: 1:500-1:2000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200;

WB, IHC-P, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG