IL-10 Antibody (YA4644)

IL-10 Antibody is an unconjugated, approximately 21 kDa, rabbit-derived, anti-IL-10 monoclonal antibody. IL-10 Antibody can be used for: WB, IF-Cell, IHC-P expriments in human, mouse, rat background without labeling.

The protein encoded by The related gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. The cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. The cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of The cytokine as an essential immunoregulator in the intestinal tract. Mutations in The related gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

P22301

Predicted band size: 21 kDa

affinity purified

Secreted.

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal, Recombinant

Rabbit

Human, Mouse, Rat

WB: 1:1,000; IF-Cell: 1:500; IHC-P: 1:1,000

WB, IHC-P, ICC/IF

THP-1 cell lysate, THP-1 treated with 800nM TPA overnight then treated with 100ng/mL LPS for 6 hours add 300ng/mL BFA for 3 hours cell lysate, mouse spleen tissue lysate, rat spleen tissue lysate, THP

Liquid

Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Synthetic peptide within Human IL-10 aa 1-100.