HP1-γ Antibody (YA5185)

HP1-γ Antibody (YA5185) is a mouse-derived and non-conjugated monoclonal antibody, targeting to HP1-γ. It can be applicated for WB, ICC/IF, IP, IHC-P assays, in the background of mouse, human, monkey, hamster, rat.

HP1γ is a protein involved in transcriptional silencing within heterochromatin-like complexes. It recognizes and binds to histone H3 tails methylated at Lys-9, leading to epigenetic repression. Through its interaction with the lamin B receptor (LBR), HP1γ may facilitate the association of heterochromatin with the inner nuclear membrane. Additionally, it participates in the formation of functional kinetochores via interaction with MIS12 complex proteins. HP1γ contributes to the conversion of local chromatin into a heterochromatin-like repressive state by promoting H3 Lys-9 trimethylation and recruits the methyltransferases SUV39H1 and/or SUV39H2 to the E-box elements of circadian target genes (e.g., PER2 or PER1) through the PER complex. It also mediates the recruitment of NIPBL to double-strand break (DSB) damage sites.

Q13185

Observed band size: 22 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Mouse, Human, Monkey, Hamster, Rat

WB: 1:1000; ICC: 1:200; ICC/IF: 1:50-200

WB, ICC/IF, IP, IHC-P

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human HP1-gamma protein fragments expressed in E.coli.