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  4. hnRNP C1/C2 Antibody (YA1874)

hnRNP C1/C2 Antibody (YA1874)

Cat. No.: HY-P82129
COA User Guide for Antibodies Technical Support

hnRNP C1/C2 Antibody (YA1874) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1874), targeting hnRNP C1/C2, with a predicted molecular weight of 34 kDa (observed band size: 40 kDa). hnRNP C1/C2 Antibody (YA1874) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL In-stock
50 μL In-stock
100 μL In-stock
250 μL   Get quote  

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

hnRNP C1/C2 Antibody (YA1874) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1874), targeting hnRNP C1/C2, with a predicted molecular weight of 34 kDa (observed band size: 40 kDa). hnRNP C1/C2 Antibody (YA1874) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

Background

hnRNP C1/C2 is an RNA-binding protein that binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. It interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA, modulating the stability and translation efficiency of bound mRNA molecules. A single HNRNPC tetramer binds 230-240 nucleotides, while trimers of HNRNPC tetramers bind 700 nucleotides. This protein may play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Additionally, N6-methyladenosine (m6A) can alter the local structure of mRNAs and long non-coding RNAs (lncRNAs) through an 'm6A-switch' mechanism, facilitating HNRNPC binding and thereby regulating mRNA splicing.

Gene ID
SwissProt ID
Synonyms
HNRNPC; HNRPC; Heterogeneous nuclear ribonucleoproteins C1/C2; hnRNP C1/C2
Molecular Weight

Predicted band size: 34 kDa; Observed band size: 40 kDa

Purity

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

RRID
Research Field

Epigenetics and Nuclear Signaling

Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Clonality

Recombinant, Monoclonal

Host

Rabbit

Reactivity

Human, Mouse, Rat

Dilution Ratio

WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200;IP: 1/50;FC: 1/50-1/100

Application

WB, IHC-P, ICC/IF, IP, FC

Appearance

Liquid

Formulation

Supplied in Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Isotype

IgG

Sensitivity

Endogenous

Immunogen

A synthesized peptide derived from human hnRNP C1/C2

Database
Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
hnRNP C1/C2 Antibody (YA1874)
Cat. No.:
HY-P82129
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