GSK3 alpha Antibody (YA2971)

Cat. No.: HY-P83226: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

GSK3 alpha Antibody (YA2971) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2971), targeting GSK3 alpha, with a predicted molecular weight of 51 kDa (observed band size: 51 kDa). GSK3 alpha Antibody (YA2971) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

GSK3 alpha Antibody (YA2971) Featured Recommendations:

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

Biological Activity
Technical Parameters
Properties
Documentation

Description	GSK3 alpha Antibody (YA2971) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2971), targeting GSK3 alpha, with a predicted molecular weight of 51 kDa (observed band size: 51 kDa). GSK3 alpha Antibody (YA2971) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.
Background	GSK3α protein, a constitutively active kinase, plays a crucial role as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling, and transcription factor and microtubule regulation. It exerts its regulatory function by phosphorylating and inactivating key targets such as glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC, and AXIN1. Primed phosphorylation is a requisite for the majority of its substrates. GSK3α contributes to insulin's control of glycogen synthesis by inhibiting GYS1 activity and thus glycogen synthesis, particularly in the liver. Additionally, it is implicated in the regulation of insulin resistance and plays a role in Wnt signaling by modulating the level and transcriptional activity of nuclear CTNNB1/beta-catenin. GSK3α also participates in amyloid precursor protein (APP) processing associated with Alzheimer's disease, regulates replication in pancreatic beta-cells, and is crucial for the establishment of neuronal polarity and axon outgrowth. Furthermore, it controls cell apoptosis in response to growth factor deprivation, negatively regulates the extrinsic apoptotic signaling pathway, and promotes the formation of an anti-apoptotic complex at death receptors. GSK3α also acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, promoting acetylation of key autophagy regulators. Additionally, it negatively regulates the mTORC2 complex by phosphorylating RICTOR, leading to its ubiquitination and degradation.
Gene ID	2931 [NCBI]
SwissProt ID	P49840
Synonyms	Serine/threonine-protein kinase GSK3A
Molecular Weight	Predicted band size: 51 kDa; Observed band size: 51 kDa
Purity	Affinity Purified
Conjugation	Non-conjugated
Modification	Unmodified
Research Field	Neuroscience
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human, Mouse, Rat
Dilution Ratio	WB: 1/500-1/1000;IF: 1/50-1/200;IP: 1/20
Application	WB, ICC/IF, IP
Appearance	Liquid
Formulation	Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	A synthetic peptide of human GSK3 alpha
Database	Entrez Gene: 2931 Human ; 606496 Mouse ; 50686 Rat SwissProt: P49840 Human ; Q2NL51 Mouse ; P18265 Rat OMIM: 606784 Human
Documentation	Select Batch: Data Sheet (236 KB) SDS (251 KB) COA (191 KB) User Guide for Antibodies (1077 KB)

GSK3 alpha Antibody (YA2971) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Country or Region *

Email Address *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

GSK3 alpha Antibody (YA2971)

GSK3 alpha Antibody (YA2971) Featured Recommendations:

Biological Activity

Technical Parameters

Properties

Documentation

GSK3 alpha Antibody (YA2971) Related Classifications

Your Recently Viewed Products:

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report