FGFR3 Antibody (YA3887)

FGFR3 Antibody (YA3887) is a mouse-derived and non-conjugated IgG1 antibody, targeting to FGFR3. It can be applicated for IHC-P, FC, ELISA assays, in the background of human.

FGFR3 is a tyrosine-protein kinase that functions as a cell-surface receptor for fibroblast growth factors (FGFs) and plays essential roles in regulating cell proliferation, differentiation, and apoptosis. It is critically involved in chondrocyte differentiation, proliferation, and apoptosis, and is required for normal skeletal development. The protein regulates both osteogenesis and postnatal bone mineralization by osteoblasts, exhibiting dual functions of promoting chondrocyte apoptosis while potentially enhancing cancer cell proliferation. FGFR3 is necessary for inner ear development and phosphorylates PLCG1, CBL, and FRS2. Ligand binding activates multiple signaling pathways: PLCG1 activation generates diacylglycerol and inositol 1,4,5-trisphosphate, while FRS2 phosphorylation mediates recruitment of GRB2, GAB1, PIK3R1, and SOS1 to activate RAS, MAPK1/ERK2, MAPK3/ERK1, MAP kinase pathways, and the AKT1 signaling pathway. It also participates in vitamin D metabolism regulation. Mutations causing constitutive kinase activation or impairing FGFR3 maturation, internalization, and degradation lead to aberrant signaling. Overexpressed or constitutively active FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A, and STAT5B. The secreted isoform 3 retains FGF1/FGF2 binding capacity and may interfere with FGF signaling.

P22607

Predicted band size: 88 kDa; Observed band size: 88 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IHC: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

IHC-P, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human FGFR3 (AA: 529-694) expressed in E. Coli.