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  4. Monoclonal Antibodies Recombinant Antibodies
  5. FADS1 Antibody (YA2910)

FADS1 Antibody (YA2910)

Cat. No.: HY-P83165
COA
SDS
User Guide for Antibodies Technical Support

FADS1 Antibody (YA2910) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2910), targeting FADS1, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). FADS1 Antibody (YA2910) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

FADS1 Antibody (YA2910) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2910), targeting FADS1, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). FADS1 Antibody (YA2910) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse, rat background.
Background

FADS1 is a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. It is involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA, 18:2n-6) and alpha-linolenic acid (ALA, 18:3n-3) precursors. Specifically, FADS1 desaturates dihomo-gamma-linoleoate (DGLA, 20:3n-6) and eicosatetraenoate (ETA, 20:4n-3) to generate arachidonate (AA, 20:4n-6) and eicosapentaenoate (EPA, 20:5n-3), respectively. As a rate-limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, FADS1 controls the metabolism of inflammatory lipids like prostaglandin E2, which is critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Additionally, FADS1 contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. Notably, it regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (by similarity). FADS1 also desaturates (11E)-octadecenoate (trans-vaccenoate, 18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (by similarity). It is important to note that FADS1 does not exhibit catalytic activity toward 20:3n-6, but it may enhance FADS2 activity.
Gene ID
SwissProt ID
Synonyms
D5D; TU12; FADS6; FADSD5; LLCDL1
Molecular Weight

Predicted band size: 52 kDa; Observed band size: 52 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Research Field

Tags & Cell Markers
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200
Application

WB, IHC-F, IHC-P, ICC/IF
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthetic peptide of human FADS1
Database

Entrez Gene: 3992 Human ; 76267 Mouse ; 84575 Rat

SwissProt: O60427 Human ; Q920L1 Mouse ; Q920R3 Rat

OMIM: 606148 Human

Documentation
SDS (251 KB)

COA (191 KB)

User Guide for Antibodies (1077 KB)

FADS1 Antibody (YA2910) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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