Desmin Antibody (YA3836)

Desmin Antibody (YA3836) is a mouse-derived and non-conjugated IgG1 antibody, targeting to Desmin. It can be applicated for WB, IHC-P, FC, ELISA assays, in the background of human, mouse, rat, rabbit, monkey.

Desmin is a muscle-specific type III intermediate filament essential for proper muscular structure and function. It plays a crucial role in maintaining sarcomere structure by interconnecting Z-disks and forming myofibrils, linking them to the sarcolemmal cytoskeleton, nucleus, and mitochondria, thereby providing strength during muscle activity. In adult striated muscle, Desmin forms a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of Z-line structures. It may act as a sarcomeric microtubule-anchoring protein, specifically associating with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Additionally, Desmin is required for nuclear membrane integrity via anchoring at the cell tip and nuclear envelope, maintaining microtubule-derived intracellular mechanical forces (by similar). It contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during cardiomyogenesis and in cardiac side population stem cells, and plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (by similar).

P17661

Predicted band size: 54 kDa; Observed band size: 54 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human, Mouse, Rat, Rabbit, Monkey

WB: 1/500-1/2000; IHC: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

WB, IHC-P, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of Desmin expressed in E. Coli.