CrkL Antibody (YA2577)

CrkL Antibody (YA2577) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2577), targeting CrkL, with a predicted molecular weight of 34 kDa (observed band size: 39 kDa). CrkL Antibody (YA2577) can be used for WB, IHC-P, ICC/IF experiment in human background.

The CRKL protein is implicated in mediating the transduction of intracellular signals, indicating its role in cellular signaling pathways. It interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1, suggesting its involvement in pathways associated with erythropoietin receptor signaling and phosphoinositide signaling. Additionally, CRKL interacts with DOCK2 and DOCK5 via its first SH3 domain, highlighting its potential role in modulating guanine nucleotide exchange factors. The protein further engages with phosphorylated CBLB and IRS4, indicating its participation in pathways related to cellular proliferation and insulin receptor signaling. Furthermore, CRKL interacts with BCAR1/CAS and NEDD9/HEF1, suggesting its involvement in signaling cascades associated with cell adhesion and migration. These diverse interactions underscore the versatility of CRKL in transmitting signals within the cell.

P46109

Predicted band size: 34 kDa; Observed band size: 39 kDa

Affinity Purified

Non-conjugated

Unmodified

Neuroscience

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200

WB, IHC-P, ICC/IF

Liquid

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human CRKL