2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. COPS8 Antibody (YA1679)

COPS8 Antibody (YA1679)

Cat. No.: HY-P81934
COA
SDS
User Guide for Antibodies Technical Support

COPS8 Antibody (YA1679) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1679), targeting COPS8, with a predicted molecular weight of 23 kDa (observed band size: 23 kDa). COPS8 Antibody (YA1679) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

COPS8 Antibody (YA1679) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1679), targeting COPS8, with a predicted molecular weight of 23 kDa (observed band size: 23 kDa). COPS8 Antibody (YA1679) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.
Background

COPS8 is a component of the COP9 signalosome complex (CSN), which participates in various cellular and developmental processes. The CSN complex acts as a crucial regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of cullin subunits in SCF-type E3 ligase complexes (e.g., SCF, CSA, or DDB2), thereby reducing their Ubl ligase activity. Additionally, through its association with CK2 and PKD kinases, the complex is involved in the phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, and IRF8/ICSBP. CSN-dependent phosphorylation of TP53 and JUN promotes and protects their degradation by the Ubl system, respectively.
Gene ID
SwissProt ID
Synonyms
COP9 signalosome subunit 8; COP9; CSN8; SGN8
Molecular Weight

Predicted band size: 23 kDa; Observed band size: 23 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Research Field

Immunology
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200;IP: 1/20
Application

WB, IHC-F, IHC-P, ICC/IF, IP
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthetic peptide of human COPS8
Database

Entrez Gene: 10920 Human ; 108679 Mouse ; 363283 Rat

SwissProt: Q99627 Human ; Q8VBV7 Mouse ; Q6P4Z9 Rat

OMIM: 616011 Human

Documentation
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

COPS8 Antibody (YA1679) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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COPS8 Antibody (YA1679)
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