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  5. UQCRC2 Antibody (YA1929)

UQCRC2 Antibody (YA1929) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to UQCRC2.

For research use only. We do not sell to patients.

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50 μL In-stock
100 μL In-stock
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

UQCRC2 Antibody (YA1929) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to UQCRC2.
Background

Complex III Subunit 2 is a component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that forms part of the mitochondrial electron transport chain, driving oxidative phosphorylation. The respiratory chain consists of three multisubunit complexes: succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), and cytochrome c oxidase (complex IV, CIV), which work together to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient across the inner membrane that powers transmembrane transport and ATP synthase. The cytochrome b-c1 complex facilitates electron transfer from ubiquinol to cytochrome c, coupling this redox reaction to proton translocation across the mitochondrial inner membrane, with protons being transported as hydrogens on the quinol. In the Q cycle, two protons are consumed from the matrix, four protons are released into the intermembrane space, and two electrons are transferred to cytochrome c (By similarity). The two core subunits, UQCRC1/QCR1 and UQCRC2/QCR2, are homologous to the mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP, respectively, and appear to retain MPP processing properties (By similarity). This subunit may also be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 upon incorporation into complex III (Probable).
Gene ID
SwissProt ID
Synonyms
Core protein II; QCR2; mitochondrial; Ubiquinol cytochrome c reductase core protein II; UQCR2; Uqcrc2
Molecular Weight

Predicted band size: 48 kDa; Observed band size: 48 kDa
Purity

Affinity Chromatography
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Signal Transduction
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1:500-1:1000; IHC: 1:50-1:100; IF: 1:50-1:200; IP: 1:50; FC: 1:50-1:100
Application

WB, IHC-P, ICC/IF, IP, FC
Appearance

Liquid
Formulation

Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthesized peptide derived from human UQCRC2
Database

Entrez Gene: 7385 Human ; 67003 Mouse ; 293448 Rat

SwissProt: P22695 Human ; Q9DB77 Mouse ; P32551 Rat

OMIM: 615160 Human

Documentation
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

UQCRC2 Antibody (YA1929) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
UQCRC2 Antibody (YA1929)
Cat. No.:
HY-P82184
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