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  2. Primary Antibodies
  3. Monoclonal Antibodies
  4. CD354 Antibody (YA4511)

CD354 Antibody (YA4511)

Cat. No.: HY-P84814
User Guide for Antibodies Technical Support

CD354 Antibody (YA4511) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CD354. It can be applicated for WB, FC, ELISA assays, in the background of human, rat, monkey.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

CD354 Antibody (YA4511) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CD354. It can be applicated for WB, FC, ELISA assays, in the background of human, rat, monkey.

Background

CD354 is a cell surface receptor that plays a crucial role in innate and adaptive immunity by amplifying inflammatory responses upon activation by ligands such as PGLYRP1, HMGB1, or HSP70. Upon activation, it multimerizes and forms a complex with the transmembrane adapter TYROBP/DAP12, initiating a SYK-mediated tyrosine phosphorylation cascade that activates downstream mediators like BTK, MAPK1, MAPK3, or phospholipase C-gamma. This cascade promotes the release of pro-inflammatory cytokines and/or chemokines by neutrophils and macrophages, enhancing their migration and amplifying inflammatory responses triggered by bacterial and fungal infections. Additionally, CD354 enhances inflammatory signals initiated by Toll-like receptors (TLRs) and NOD-like receptors, playing a key role in the pathophysiology of acute and chronic inflammatory diseases such as septic shock and atherosclerosis. It also acts as a decoy receptor, counterbalancing TREM1's pro-inflammatory activity by neutralizing its ligands.

Gene ID
SwissProt ID
Synonyms
TREM1; TREM-1
Molecular Weight

Predicted band size: 26.4 kDa; Observed band size: 44 kDa

Purity

affinity purified.

Conjugation

Non-conjugated

Product Categories

Primary Antibody; Mouse Monoclonal Antibody

Host

Mouse

Reactivity

Human, Rat, Monkey

Dilution Ratio

WB: 1/500-1/2000; FC: 1/200-1/400; ELISA: 1/10000

Application

WB, FC, ELISA

Appearance

Liquid

Formulation

Supplied in PBS with 0.05% sodium azide

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Isotype

IgG1

Immunogen

Purified recombinant fragment of human CD354 (AA: extra 21-205) expressed in E. Coli.

Documentation

CD354 Antibody (YA4511) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
CD354 Antibody (YA4511)
Cat. No.:
HY-P84814
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