CD248 Antibody (YA4508)

CD248 Antibody (YA4508) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CD248. It can be applicated for FC, ELISA assays, in the background of human.

CD248 is a cell surface glycoprotein involved in various biological processes, including angiogenesis, immune response modulation, and tissue remodeling and repair. It participates in pericyte proliferation through positive modulation of the PDGF receptor signaling pathway. CD248 acts as a scaffold for factor X, triggering allosteric changes and the spatial re-alignment of factor X with the TF-factor VIIa complex, thereby enhancing coagulation activation. Additionally, CD248 modulates the insulin signaling pathway by interacting with the insulin receptor (INSR) and diminishing its autophosphorylation capacity in response to insulin. In macrophages, it regulates LPS-induced inflammatory responses by promoting the production of proinflammatory cytokines. In humans, CD248 negatively regulates T-cell proliferation compared to stromal cells, where it increases proliferation.

Q9HCU0

Predicted band size: 80.9 kDa; Observed band size: 160 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

FC: 1/200-1/400; ELISA: 1/10000

FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human CD248 (AA: extra 18-180) expressed in E. Coli.