CD191 Antibody (YA3957)

CD191 Antibody (YA3957) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD191.

CD191 is a chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses. It recruits immune cells such as monocytes, macrophages, T-cells, and dendritic cells to sites of inflammation for pathogen clearance and tissue repair. Upon activation by ligands including CCL3, CCL5-9, CCL13-16, and CCL23, it triggers intracellular signaling cascades that direct cell migration toward the chemokine source. For example, it mediates neutrophil migration after CCL3 activation, accompanied by the release of TNF-alpha and leukotriene B4 (by similar). Additionally, it facilitates monocyte migration upon CXCL4 binding, while CCL5 activation induces neuroinflammation via the ERK1/2 signaling pathway (by similar).

P32246

Predicted band size: 41 kDa; Observed band size: 41 kDa0

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal Antibody

Mouse

Human

WB: 1:500-1:2000; FC: 1:200-1:400; ELISA: 1:10000

WB, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human CD191 (AA: extra mix) expressed in E. Coli.