Caspr2 Antibody (YA2970)

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Caspr2 Antibody (YA2970) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2970), targeting Caspr2, with a predicted molecular weight of 148 kDa (observed band size: 160 kDa). Caspr2 Antibody (YA2970) can be used for WB, IHC-P experiment in human, mouse, rat background.

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Size	Stock	Quantity
10 μL	Get quote 4 - 5 weeks 3 - 4 weeks 3 - 4 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 4 - 5 weeks 3 - 4 weeks 3 - 4 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 4 - 5 weeks 3 - 4 weeks 3 - 4 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

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Description	Caspr2 Antibody (YA2970) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2970), targeting Caspr2, with a predicted molecular weight of 148 kDa (observed band size: 160 kDa). Caspr2 Antibody (YA2970) can be used for WB, IHC-P experiment in human, mouse, rat background.
Background	CASPR2 Protein exhibits PDZ domain binding activity and is involved in diverse processes such as chemical synaptic transmission, nervous system development, and synapse organization. It plays a crucial role upstream of or within processes like glutamatergic neuron differentiation, limbic system development, and neuron projection development. CASPR2 is located in various cellular components, including the cerebellar granule cell to Purkinje cell synapse, main axon, and presynaptic active zone membrane, and serves as an integral component of the membrane and the voltage-gated potassium channel complex. Active in dendrites and excitatory synapses, CASPR2 is prominently expressed in the central nervous system and neural retina. It has been studied in the context of autism spectrum disorder and cortical dysplasia-focal epilepsy syndrome. Additionally, its human ortholog(s), particularly CNTNAP2 (contactin-associated protein 2), are implicated in diseases such as Pitt-Hopkins syndrome, autism spectrum disorder, communication disorder, cortical dysplasia-focal epilepsy syndrome, and social phobia. The gene demonstrates biased expression in CNS E18 (RPKM 4.2), whole brain E14.5 (RPKM 3.7), and seven other tissues, highlighting its involvement in critical developmental and neurological processes across various tissues.
Gene ID	26047 [NCBI]
SwissProt ID	Q9UHC6
Synonyms	AUTS15; CDFE; CNTNAP2; CNTP2; NRXN4; PTHSL1
Molecular Weight	Predicted band size: 148 kDa; Observed band size: 160 kDa
Purity	Affinity Purified
Conjugation	Non-conjugated
Modification	Unmodified
Research Field	Neuroscience
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human, Mouse, Rat
Dilution Ratio	WB: 1/500-1/1000;IHC: 1/50-1/100
Application	WB, IHC-P
Appearance	Liquid
Formulation	Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	A synthesized peptide derived from human CNTP2
Database	Entrez Gene: 26047 Human ; 66797 Mouse ; SwissProt: Q9UHC6 Human ; Q9CPW0 Mouse OMIM: 612100 Human
Documentation	Data Sheet (235 KB) User Guide for Antibodies (1077 KB)

Caspr2 Antibody (YA2970) Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Caspr2 Antibody (YA2970)

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