BACH1 Antibody (YA4463)

BACH1 Antibody (YA4463) is a mouse-derived and non-conjugated IgG1 antibody, targeting to BRIP1. It can be applicated for IHC-P, FC, ELISA assays, in the background of human.

BACH1 is a DNA-dependent ATPase and 5'-3' DNA helicase essential for maintaining chromosomal stability. It acts late in the Fanconi anemia pathway, following FANCD2 ubiquitination. BACH1 participates in homologous recombination repair of DNA double-strand breaks through its association with BRCA1 and facilitates the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links. Its helicase activity unfolds HMCES DNA-protein cross-links, enabling SPRTN metalloprotease to cleave the adduct. Additionally, BACH1 unwinds RNA:DNA substrates and G-quadruplex DNA (the latter requiring a 5'-single-stranded tail). by similar: BACH1 is involved in diverse DNA repair mechanisms, including homologous recombination and cross-link repair.

Q9BX63

Predicted band size: 141 kDa; Observed band size: 105 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IHC: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

IHC-P, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human BRIP1 (AA: 904-986) expressed in E. Coli.