BRAT1 Antibody (YA2294)

BRAT1 Antibody (YA2294) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2294), targeting BRAT1, with a predicted molecular weight of 88 kDa (observed band size: 88 kDa). BRAT1 Antibody (YA2294) can be used for WB, ICC/IF, IP experiment in human background.

BRAT1 is a component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex. It associates with INTS9 and INTS11 in the cytoplasm, blocking the active site of INTS11 to inhibit its endonuclease activity prior to full integrator complex formation. After dissociation of WDR73, BRAT1 facilitates nuclear import of the INTS9-INTS11 heterodimer. In the nucleus, INTS4 is integrated into the heterodimer, and BRAT1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6). BRAT1 also participates in DNA damage response by activating kinases ATM, SMC1A, and PRKDC through phosphorylation modulation following ionizing radiation (IR) stress. Additionally, it regulates mitochondrial function and cell proliferation, maintains protein stability of MTOR and related proteins, and promotes growth factor-dependent cell cycle progression.

Q6PJG6

Predicted band size: 88 kDa; Observed band size: 88 kDa

Affinity Purified

Non-conjugated

Unmodified

Epigenetics and Nuclear Signaling

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1/500-1/1000;IF: 1/50-1/200;IP: 1/20

WB, ICC/IF, IP

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Recombinant protein of human BRAT1