beta-Dystroglycan Antibody (YA2751)

beta-Dystroglycan Antibody (YA2751) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to beta-Dystroglycan.

beta Dystroglycan is a transmembrane glycoprotein that plays a crucial role in linking the extracellular matrix to the cytoskeleton. It functions as a cell adhesion receptor in both muscle and non-muscle tissues, participating in processes such as laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. As a receptor for extracellular matrix proteins containing laminin-G domains, it binds to laminin-2 (LAMA2) and agrin in Schwann cells (by similar). It also interacts with DMD and UTRN to scaffold axin to the cytoskeleton and is involved in cell adhesion-mediated signaling and cell polarity. In microbial infections, beta Dystroglycan serves as a receptor for lassa virus, lymphocytic choriomeningitis virus glycoprotein, and class C new-world arenaviruses, as well as a Schwann cell receptor for Mycobacterium leprae (requiring the G-domain of LAMA2).

Q14118

Predicted band size: 97 kDa; Observed band size: 42-44 kDa

Affinity Purified

Non-conjugated

Unmodified

-

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1:500-1:1000

WB

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthetic peptide of human beta Dystroglycan