Armenian Hamster Anti-Mouse CD80 Antibody (PE) (YA3448)

Armenian Hamster Anti-Mouse CD80 Antibody (PE) (YA3448) is an Armenian hamster-derived and phycoerythrin (PE) IgG monoclonal antibody, targeting to CD80.

Armenian Hamster Anti-Mouse CD80 is a costimulatory molecule belonging to the immunoglobulin superfamily that plays a crucial role in T-lymphocyte activation. It acts as the primary auxiliary signal, enhancing the MHC/TCR signal in naive T-cells together with the CD28 receptor, which is constitutively expressed on T-cell surfaces. Additionally, the CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis in T-cells by activating the PI3K/Akt signaling pathway. It also regulates PDL1/PDCD1 interactions to limit excessive engagement of PDL1 and its inhibitory role in immune responses. Expressed on B-cells, it is critical for regulating interactions between B-cells and T-cells during both early and late germinal center responses, which are essential for generating effective humoral immune responses.

Q00609

Predicted band size: 35 kDa; Observed band size: 68 kDa

Affinity Purified

PE

Unmodified

Primary Antibody; Flow Cytometry Antibody

Monoclonal

Armenian hamster

Mouse

FC: 5μL per test for million cells or whole blood in 100 μL volume.

FC

Liquid

Supplied in PBS with 0.05% Proclin300, 1% BSA.

Stored at 2-8°C for 1 year, protect from light, do not freeze.

Shipping with blue ice.

IgG

A synthesized peptide derived from Mouse CD80.