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  5. ARF6 Antibody (YA3016)

ARF6 Antibody (YA3016) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3016), targeting ARF6, with a predicted molecular weight of 20 kDa. ARF6 Antibody (YA3016) can be used for WB, ICC/IF experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

ARF6 Antibody (YA3016) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3016), targeting ARF6, with a predicted molecular weight of 20 kDa. ARF6 Antibody (YA3016) can be used for WB, ICC/IF experiment in human, mouse, rat background.
Background

ARF6 is a GTP-binding protein involved in protein trafficking, regulating endocytic recycling and cytoskeleton remodeling. The GTP-bound form plays a key role in transporting multiple palmitoylated proteins from the Golgi to the plasma membrane. It is required for the normal completion of mitotic cytokinesis (by similar) and contributes to actin cytoskeleton reorganization and stress fiber formation (by similar). ARF6 regulates dendritic spine development, promoting dendritic branching and filopodia extension. By interacting with the molecular adapter APBB1, it potentiates neurite outgrowth in primary neurons. Additionally, ARF6 plays a role in membrane trafficking, junctional remodeling, and epithelial polarization. It regulates surface levels of adherens junction proteins like CDH1 (by similar) and is involved in sorting NTRK1 to the recycling pathway from early endosomes (by similar). In microbial infection, ARF6 acts as an allosteric activator of the cholera toxin catalytic subunit and is essential for enterovirus 71 endocytosis, facilitating viral entry into brain microvascular endothelial cells.
Gene ID
SwissProt ID
Synonyms
ADP ribosylation factor 6; ARF6; Small GTP binding protein
Molecular Weight

Predicted band size: 20 kDa; Observed band size: 20 kDa
Purity

Affinity Chromatography
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Research Field

Signal Transduction
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1/500-1/1000;IF: 1/50-1/200
Application

WB, ICC/IF
Appearance

Liquid
Formulation

Supplied in Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthesized peptide derived from human ARF6
Database

Entrez Gene: 382 Human ; 11845 Mouse ; 79121 Rat

SwissProt: P62330 Human ; P62331 Mouse ; P62332 Rat

OMIM: 600464 Human

Documentation
SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

ARF6 Antibody (YA3016) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
ARF6 Antibody (YA3016)
Cat. No.:
HY-P83271
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