AKR1C3 Antibody (YA2338)

AKR1C3 Antibody (YA2338) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2338), targeting AKR1C3, with a predicted molecular weight of 37 kDa (observed band size: 37 kDa). AKR1C3 Antibody (YA2338) can be used for WB, ICC/IF, IP, FC experiment in human background.

AKR1C3 is a cytosolic aldo-keto reductase that catalyzes the NADH- and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Functioning as an NAD§(H)-dependent 3-, 17-, and 20-ketosteroid reductase on the steroid nucleus and side chain, it regulates the metabolism of androgens, estrogens, and progesterone. While demonstrating both oxidative and reductive catalytic activities in vitro, it primarily acts as a reductase in vivo due to inhibition of its oxidase activity by physiological concentrations of NADPH. AKR1C3 preferentially serves as a 17-ketosteroid reductase and exhibits the highest catalytic efficiency among AKR1C enzymes for reducing delta4-androstenedione to testosterone. Additionally, it reduces prostaglandin D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone, estrone to 17beta-estradiol, and converts the potent androgen dihydrotestosterone (DHT) into the less active 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). by similar: The enzyme also displays retinaldehyde reductase activity toward 9-cis-retinal.

P42330

Predicted band size: 37 kDa; Observed band size: 37 kDa

Affinity Chromatography

Non-conjugated

Unmodified

AB_3104694

Signal Transduction

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1/500-1/1000;IF: 1/50-1/200;IP: 1/30;FC: 1/50-1/100

WB, ICC/IF, IP, FC

Liquid

Supplied in Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human AKR1C3