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  5. ADAM10 Antibody (YA3292)

ADAM10 Antibody (YA3292)

Cat. No.: HY-P83547
COA
SDS
User Guide for Antibodies Technical Support

ADAM10 Antibody (YA3292) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3292), targeting ADAM10, with a predicted molecular weight of 84 kDa (observed band size: 84 kDa). ADAM10 Antibody (YA3292) can be used for WB, IP experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

ADAM10 Antibody (YA3292) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3292), targeting ADAM10, with a predicted molecular weight of 84 kDa (observed band size: 84 kDa). ADAM10 Antibody (YA3292) can be used for WB, IP experiment in human, mouse, rat background.
Background

The ADAM10 protein serves as a multifaceted protease with a broad substrate specificity, playing a central role in diverse biological processes. Notably, ADAM10 cleaves the membrane-bound precursor of TNF-alpha, releasing its mature soluble form. Additionally, it is responsible for the proteolytic release of various cell-surface proteins, including JAM3, heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2, and the constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). ADAM10 contributes to the normal cleavage of the cellular prion protein and is involved in the cleavage of adhesion molecules such as L1. Furthermore, it controls the proteolytic processing of Notch, mediates lateral inhibition during neurogenesis, and is responsible for FasL ectodomain shedding. ADAM10 exhibits a versatile role in mediating the proteolytic cleavage of various integral membrane proteins, including CORIN, ITM2B, LAG3, IL6R, IL11RA, CHL1, NRCAM, and TREM2. Additionally, ADAM10 plays a crucial role in the development and maturation of glomerular and coronary vasculature, contributes to pillar cell separation during the development of the cochlear organ of Corti, and regulates EFNA5-EPHA3 signaling. In microbial infection, ADAM10 promotes the cytotoxic activity of S.aureus hly by binding to the toxin at zonula adherens and promoting the formation of toxin pores.
Gene ID
SwissProt ID
Synonyms
CDw156; CD156c; ADAM10; KUZ; MADM
Molecular Weight

Predicted band size: 84 kDa; Observed band size: 84 kDa
Purity

Affinity Chromatography
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Research Field

Cell Biology
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1/500-1/1000;IP: 1/50
Application

WB, IP
Appearance

Liquid
Formulation

Supplied in Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthesized peptide derived from human ADAM10
Database

Entrez Gene: 102 Human ; 11487 Mouse ; 29650 Rat

SwissProt: O14672 Human ; O35598 Mouse ; Q10743 Rat

OMIM: 615537 Human

Documentation
SDS (251 KB)

COA (191 KB)

User Guide for Antibodies (1077 KB)

ADAM10 Antibody (YA3292) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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ADAM10 Antibody (YA3292)
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