Anti-GPC-2 Antibody (CT3)

Cat. No.: HY-P990842: Data Sheet
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Anti-GPC-2 Antibody (CT3) is a kind of mouse IgG1 κ chimeric antibody, targeting to human GPC-2. Anti-GPC-2 Antibody (CT3) reacts with tumor-associated exons 3 and 10 of glypicans-2 (GPC2). Anti-GPC-2 Antibody (CT3) can be used for the research of cancer, such as neuroblastoma.

For research use only. We do not sell to patients.

Anti-GPC-2 Antibody (CT3) Chemical Structure

Size		Stock
MOQ		Minimum order quantity
1 mg		Get quote
5 mg		Get quote
10 mg		Get quote
Other size		Get quote

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Purity & Documentation
References
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Description

Isotype

Mouse IgG1 kappa

Species Reactivity

Human

IC₅₀ & Target

GPC-2

In Vitro

Anti-GPC-2 Antibody (CT3) (1 μg/mL) binds to tumor-associated exons 3 and 10 of GPC2^[1].
Anti-GPC-2 Antibody (CT3) (CAR T cells harboring the single-chain variable fragment (scFv) of the CT3) (24 h) kills nearly 70% of GPC2-overexpressing A431 and IMR5 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-GPC-2 Antibody (CT3) (CAR T cells harboring the single-chain variable fragment (scFv) of the CT3) (10 M, i.v.) regresses tumor and prolongs survival in IMR5 tumor NSG mice^[1].
Anti-GPC-2 Antibody (CT3) (CAR T cells harboring the single-chain variable fragment (scFv) of the CT3) (2 M, i.v.) regresses tumor and prolongs survival in NBEB tumor NSG mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	IMR5 tumor mice (5-week, female, NSG mice)^[1]
Dosage:	10 M (CAR T cells harboring the single-chain variable fragment (scFv) of the CT3)
Administration:	Intravenously injection
Result:	Led to a reduction in tumor size and suppressed tumor growth. Prolonged survival of mice.

Gene ID

71951 [NCBI]

Accession

Q8BKV1

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

SMILES

[Anti-GPC-2 Antibody (CT3)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Li N, et al. CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice. Cell Rep Med. 2021 Jun 1;2(6):100297. [Content Brief]

Anti-GPC-2 Antibody (CT3) Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-GPC-2 Antibody (CT3)Glycoprotein VIGPVIGPC-2NeuroblastomaA431IMR5NBEBInhibitorinhibitorinhibit

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