Anti-CD32/FcγRIIA Antibody (IV.3)

Cat. No.: HY-P990863 Purity: ≥95.0%: Data Sheet
COA

SDS

FAQs
Technical Support

Anti-CD32/FcγRIIA Antibody (IV.3) is a kind of mouse IgG2b chimeric antibody inhibitor, targeting to human CD32/FcγRIIA. Anti-CD32/FcγRIIA Antibody (IV.3) can block Fc receptor IIA. Anti-CD32/FcγRIIA Antibody (IV.3) can be used for the researches of inflammation and infection, such as arthritis and E. coli infection.

For research use only. We do not sell to patients.

Anti-CD32/FcγRIIA Antibody (IV.3) Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Anti-CD32/FcγRIIA Antibody (IV.3) Featured Recommendations:

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Isotype

Mouse IgG2b

Recommend Isotype Controls

Mouse IgG2b kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

CD32/FcγRIIA

In Vitro

Anti-CD32/FcγRIIA Antibody (IV.3) (10 μg/mL, 30 mins) reduces uptake of S. aureus or E. coli by by skin-derived and in vitro-generated Langerhans cells and dermal DCs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-CD32/FcγRIIA Antibody (IV.3) (F(ab′)₂ fragments) (1 mg/g, i.v., every 2 days) inhibits arthritis development in transgenic hFcγRIIA mice subjected to the collagen antibody-induced arthritis (CAIA) model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Transgenic hFcγRIIA mice subjected to the collagen antibody-induced arthritis (CAIA) model^[2]
Dosage:	1 mg/g
Administration:	Intravenously injection, every 2 days
Result:	Reduced ankle thickening. Decreased the production of TNF-α, IL-6, and MIP-2.

Gene ID

2212 [NCBI]

Accession

P12318

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-CD32/FcgRIIA Antibody (IV.3)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (260 KB) SDS (251 KB)

COA (233 KB)

Inhibitory Antibodies User Guide (602 KB)

References

[1]. van der Aar AM, et al. Langerhans cells favor skin flora tolerance through limited presentation of bacterial antigens and induction of regulatory T cells. J Invest Dermatol. 2013 May;133(5):1240-9. [Content Brief]

[2]. Ben Mkaddem S, et al. Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis. J Clin Invest. 2014 Sep;124(9):3945-59. [Content Brief]

Anti-CD32/FcγRIIA Antibody (IV.3) Related Classifications

Inflammation/Immunology Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-CD32/FcγRIIA Antibody (IV.3)Fc Receptor (FcR)Fc ReceptorCD32FcγRIIAFc receptorArthritisE. coliLangerhans cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *