2. Adjuvant
  3. Saponin Adjuvant

Saponin Adjuvant

Multiple saponins have been applied in vaccine adjuvants. Saponins possess a unique hemolytic effect that disrupts red blood cell membranes and have an auxiliary function in escaping endosomes. They are currently being developed for use in mRNA vaccines, ADC drugs, small nucleic acids, and other pharmaceuticals. AS01 is composed of two immunostimulants: MPLA and a lipid-based adjuvant derived from the triterpenoid glycoside (Quillaja saponaria 21, QS-21) purified from the bark extract of Quillaja saponaria Molina.

Saponin Adjuvant (7):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-101092
    QS-21 141256-04-4 99.67%
    QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18.
    QS-21
  • HY-N3522
    Platycoside E 237068-41-6 99.40%
    Platycoside E is a platycodigenin-type saponin isolated from the root of Platycodon grandiflorum with haemolytic activity and adjuvant potential. Platycoside E promotes the production of the sera OVA-specific IgG2a and IgG2b antibody in the ovalbumin (OVA)-immunized mice.
    Platycoside E
  • HY-N2216
    Polygalasaponin XXXI 79103-90-5
    Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine to protect influenza virus infection.
    Polygalasaponin XXXI
  • HY-N9517
    QS 7 208933-54-4
    QS 7 (QS 7 Api) is a saponin compound that can be extracted from the Quillaja saponaria tree. QS 7 activates immune cells, enhances their antigen presentation ability and cytokine secretion. QS 7 can be used as vaccine adjuvant for immunostimulating, anti-tumor, and anti-infectious activities.
    QS 7
  • HY-N16034
    MS 2 96552-96-4
    MS 2 (Momordica saponin II) is a vaccine adjuvant found in the seeds of perennial Momordica cochinchinensis Spreng.
    MS 2
  • HY-N15770
    VSA 2 2489675-56-9
    VSA 2, a saponin-based vaccine adjuvant, is a derivative of Momordica saponin (MS) II. VSA 2 is an immunostimulant, shows consistent enhancement of immunoglobulin G2a (IgG2a) production when it was in formulation with either ovalbumin or recombinant hemagglutinin B (rHagB) antigen.
    VSA 2
  • HY-N15952
    MS 1 96552-95-3
    MS 1 (Momordica saponin I) is a vaccine adjuvant found in the seeds of perennial Momordica cochinchinensis Spreng.
    MS 1