2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel Apoptosis
  3. Endogenous Metabolite Cholinesterase (ChE) Potassium Channel Apoptosis
  4. Uridine 5'-monophosphate disodium salt

Uridine 5'-monophosphate disodium salt  (Synonyms: 5'-​Uridylic acid disodium salt)

Cat. No.: HY-W013175 Purity: 99.90%
COA
SDS
Handling Instructions Technical Support

Uridine 5'-monophosphate (5'-Uridylic acid) disodium salt is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate disodium salt can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.

For research use only. We do not sell to patients.

Uridine 5'-monophosphate disodium salt Chemical Structure

Uridine 5'-monophosphate disodium salt Chemical Structure

CAS No. : 3387-36-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in Water In-stock
Solid
100 mg In-stock
1 g In-stock
5 g In-stock
10 g   Get quote  
50 g   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Uridine 5'-monophosphate disodium salt:

Uridine 5'-monophosphate disodium salt Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Uridine 5'-monophosphate disodium salt

View All Cholinesterase (ChE) Isoform Specific Products:

View All Isoforms
AChE BChE

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Uridine 5'-monophosphate (5'-Uridylic acid) disodium salt is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate disodium salt can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea[1][2][3].

In Vitro

Uridine 5'-monophosphate (10 mM; 6 h) disodium salt promotes late apoptosis in pig intestinal epithelial cells IPEC-J2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Uridine 5'-monophosphate disodium salt Related Antibodies

Cell Viability Assay[1]

Cell Line: IPEC-J2
Concentration: 10 mM
Incubation Time: 6 h
Result: Increased the late apoptosis rate.
In Vivo

Uridine 5'-monophosphate (476 mg; oral; daily; 10 days) disodium salt promotes apoptosis and renewal of intestinal villus tip epithelial cells in pigs, which benefits gut development and reduces the rate of diarrhea[1].
Uridine 5'-monophosphate (0.02-1 mmol/kg; i.g.; single dose) disodium salt can enhance the synthesis of CDP-choline in the brains of gerbils[2].
Uridine 5'-monophosphate (30 mg/kg; i.v.; single dose) disodium salt has protective properties for the heart in rats, preventing ischemic injury and some arrhythmias[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Piglets[1]
Dosage: 476 mg; daily; 10 days
Administration: Oral
Result: Improved daily weight gain in piglets, reduced diarrhea rates, lowered the expression of jejunal mucosal CAD and RRM2, and increased the apoptosis rate of intestinal epithelial cells.
Animal Model: Male gerbils (60-80g)[2]
Dosage: 0.02, 0.05, 0.1, 1 mmol/kg, single dose
Administration: i.g.
Result: Increased choline levels after 15 minutes, and after thirty minutes, plasma uridine and brain tissue uridine increased, with plasma and brain cytidine also rising significantly.
Animal Model: Male wistar rats (250-300 g)[3]
Dosage: 30 mg/kg, single dose
Administration: i.v.
Result: Reduced the index of myocardial ischemia changes and T-wave amplitude, decreased the frequency of ventricular premature beats, and shortened the duration of ventricular tachycardia and fibrillation.
Molecular Weight

368.14

Formula

C9H11N2Na2O9P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]([C@H](N(C1=O)C=CC(N1)=O)O2)[C@H](O)[C@H]2COP(O[Na])(O[Na])=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (135.82 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7164 mL 13.5818 mL 27.1636 mL
5 mM 0.5433 mL 2.7164 mL 5.4327 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (271.64 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.90%

SDS (419 KB)

COA (252 KB) HNMR (170 KB) RP-HPLC (192 KB) LCMS (354 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.7164 mL 13.5818 mL 27.1636 mL 67.9089 mL
5 mM 0.5433 mL 2.7164 mL 5.4327 mL 13.5818 mL
10 mM 0.2716 mL 1.3582 mL 2.7164 mL 6.7909 mL
15 mM 0.1811 mL 0.9055 mL 1.8109 mL 4.5273 mL
20 mM 0.1358 mL 0.6791 mL 1.3582 mL 3.3954 mL
25 mM 0.1087 mL 0.5433 mL 1.0865 mL 2.7164 mL
30 mM 0.0905 mL 0.4527 mL 0.9055 mL 2.2636 mL
40 mM 0.0679 mL 0.3395 mL 0.6791 mL 1.6977 mL
50 mM 0.0543 mL 0.2716 mL 0.5433 mL 1.3582 mL
60 mM 0.0453 mL 0.2264 mL 0.4527 mL 1.1318 mL
80 mM 0.0340 mL 0.1698 mL 0.3395 mL 0.8489 mL
100 mM 0.0272 mL 0.1358 mL 0.2716 mL 0.6791 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Uridine 5'-monophosphate disodium salt Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Uridine 5'-monophosphate disodium3387-36-85'-​Uridylic acid disodiumEndogenous MetaboliteCholinesterase (ChE)Potassium ChannelApoptosisKcsAIntestinal developmentHeart protectionCell apoptosisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Uridine 5'-monophosphate disodium salt
Cat. No.:
HY-W013175
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (419 KB) Français - FR (419 KB) Deutsch - DE (419 KB) Norwegian - NO (419 KB) Español - ES (419 KB) Swedish - SV (419 KB) Italian - IT (419 KB) Portuguese - PT (419 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.