2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. SHMT
  5. SHMT1 Isoform

SHMT1

 

SHMT1 Related Products (2):

Cat. No. Product Name Effect Purity
  • HY-148545
    SHMT-IN-3
    		Inhibitor ≥98.0%
    SHMT-IN-3 (Hit 1) is a SHMT1 and SHMT2 inhibitor with an IC50 of 0.53 µM for human SHMT1. SHMT-IN-3 exhibits noncompetitive inhibition against serine.
  • HY-178432
    SHMT2-IN-1
    		Inhibitor
    SHMT2-IN-1 is a potent serine hydroxymethyltransferase 2 (SHMT2) inhibitor with an IC50 of 1.21 μM and a KD of 10.6 μM. SHMT2-IN-1 binds to the folate binding site of SHMT2. SHMT2-IN-1 also inhibits SHMT1 with an IC50 of 1.83 μM. SHMT2-IN-1 can inhibit cancer cells proliferation, migration and invasion. SHMT2-IN-1 can induce cells apoptosis and ROS production and cause G2/M phase arrest. SHMT2-IN-1 can be used for the research of cancer, such as esophageal cancer.