Ser/Thr Kinase

Ser/Thr Kinase Related Products (22):

By Effects:	Substrates (2) Inhibitors (16) Activator (1) Degrader (1)

Cat. No.	Product Name	Effect	Purity

HY-161111

KVS0001	Inhibitor	99.14%
KVS0001 is a selective SMG1 inhibitor. KVS0001 elevates the expression of transcripts and proteins resulting from truncating mutations. KVS0001 increased the presentation of immune-targetable HLA class I-associated peptides from nonsense-mediated decay (NMD)-downregulated proteins on the surface of cancer cells. KVS0001 exerts anti-tumor properties and can be studied in research for NMD-related diseases, including cancer and inherited diseases.

HY-103020

BAY-1816032	Inhibitor	99.73%
BAY-1816032 is a potent and oral available BUB1 (budding uninhibited by benzimidazoles 1) kinase inhibitor with an IC₅₀ of 7 nM.

HY-P990043

Iluzanebart	Activator	98.63%
Iluzanebart is a human monoclonal IgG1 antibody and is the agonist antibody for human TREM2 (hTREM2). Iluzanebart improves the survival and function of microglia by activating the TREM2 signaling pathway to compensate for the loss of CSF1R function. Iluzanebart can be used for research of adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP).

HY-104001

BAY-524	Inhibitor	99.48%
BAY-524 is a potent Bub1 kinase inhibitor. BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC₅₀ of 450 nM. BAY-524 can be used for the research of anti-cancer in combination with other agents.

HY-162426

UNC-CA2-103	Inhibitor	99.26%
UNC-CA2-103 (compound 128) is a potent inhibitor of Tousled like kinase 2 (TLK2), with the IC₅₀ of 18 nM.

HY-173186

TLK1-IN-1	Inhibitor
TLK1-IN-1 (Compound 5n) is a TLK1 inhibitor with an IC₅₀ of 7.2 μM against TLK1B and a GI₅₀ of 2.7 μM in LNCaP cells. TLK1-IN-1 induces DNA damage and apoptosis in cancer cells, making it a potential candidate for prostate cancer research.

HY-172241

Tapencarium	Inhibitor
Tapencarium (RZL-012) is a serine/threonine kinase inhibitor. Tapencarium can reduce subcutaneous fat volume. Tapencarium is promising for research of fat-related disorders such as Dercum’s disease and aesthetic applications.

HY-P10943

APO-15	Substrate
APO-15 is a fluorogenic imaging agent targeting phosphatidylserine (PS) exposed on the cell membrane of apoptotic cells. APO-15 can selectively bind to apoptotic cells, enabling staining and imaging of apoptotic cells in a calcium-independent and wash-free manner. APO-15 is promising for research of inflammatory diseases and cancers.

HY-145725A

Baliforsen	Inhibitor
Baliforsen is an antisense oligonucleotide (16 nucleotides) designed to target myotonic dystrophy protein kinase (DMPK) mRNA and research myotonic dystrophy.

HY-116559

TIBI	Inhibitor	99.62%
TIBI is a potent and ATP-competitive inhibitor of Rio1 (IC₅₀: 0.09 μM, K_i: 0.05 μM). TIBI enhances the thermostability of the enzyme Rio1.

HY-115719

CASK-IN-1	Inhibitor	99.7%
CASK-IN-1 is a highly potent and selective CASK inhibitor with a K_d value of 0.022 μM.

HY-P3935

Arg-Gly-Tyr-Ser-Leu-Gly		99.44%
Arg-Gly-Tyr-Ser-Leu-Gly is corresponding to the sequence of residues from 21 through 26 in lysozyme. Arg-Gly-Tyr-Ser-Leu-Gly can be used as a substrate for the protein kinase, and phosphorylated at serine residue by protein kinase.

HY-P99121

Anti-Mouse CD11b Antibody (M1/70)
Anti-Mouse CD11b Antibody is an anti-mouse CD11b IgG2b antibody inhibitor derived from the host Rat.

HY-12240

B32B3	Inhibitor
B32B3 is an inhibitor of VprBP with an IC₅₀ value of 0.5 μM at the H2AT120p cell. B32B3 can suppress tumor growth.

HY-P5435

LKBtide	Substrate
LKBtide is a biological active peptide. (This is a peptide substrate that is phosphorylated by Serine/Threonine kinase 11 (STK11), also known as LKB1. LKBtide is derived from sucrose non-fermenting 1 (SNF1) protein kinase, which is normally activated by the LKB1/AMP-activated protein kinase (AMPK) signaling pathway.)

HY-10424A

Milciclib maleate	Inhibitor
Milciclib (PHA-848125) maleate is a cyclin-dependent kinase inhibitor that impairs melanoma cell growth and modulates gene expression involved in cell cycle regulation. Milciclib maleate has been shown to significantly affect the expression of various genes, including down-regulating PTTG1, contributing to its antiproliferative activity. Milciclib maleate enhances sensitivity to treatment in p53 mutated melanoma cells when combined with PTTG1 silencing.

HY-171658

R1-ICR-5	Degrader
R1-ICR-5 is a selective PROTAC degrader that targets serine/threonine-protein kinase 1 (RIPK1). R1-ICR-5 mediates the degradation of RIPK1 through VHL, thereby deregulating the TNFR1 and TLR3/4 signaling hubs, enhancing the output of NF-κB, MAPK, and IFN signaling, and simultaneously promoting the activation of RIPK3 and the induction of necroptosis. R1-ICR-5 is promising for research of cancers and inflammatory diseases. (Pink: PK68 (HY-128348); Black: linker (HY-W012241); Blue: (S,R,S)-AHPC (HY-125845).

HY-171294

Protein kinase inhibitor 16	Inhibitor
Protein kinase inhibitor 16 exhibits inhibitory activity against a variety of Ser/Thr kinase or receptor or non-receptor tyrosine kinase.

HY-171276

Anti-neuroinflammation agent 3	Inhibitor
Anti-neuroinflammation agent 3 (Compound A.10.3) exhibits inhibitory activity against a variety of Ser/Thr kinase or receptor or non-receptor tyrosine kinase.

HY-171291

Protein kinase inhibitor 14	Inhibitor
Protein kinase inhibitor 14 (Compound 13) exhibits inhibitory effects against a variety of serine/threonine kinase and receptor/non-receptor tyrosine kinase.

Name
Email *

	Sorry, but the email address you supplied was invalid.