2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Microsomal Triglyceride Transfer Protein (MTP)
  5. Microsomal Triglyceride Transfer Protein (MTP) Inhibitor

Microsomal Triglyceride Transfer Protein (MTP) Inhibitor

Microsomal Triglyceride Transfer Protein (MTP) Inhibitors (6):

Cat. No. Product Name Effect Purity
  • HY-14667
    Lomitapide
    		Inhibitor 99.63%
    Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.
  • HY-106011
    SLX-4090
    		Inhibitor 98.97%
    SLX-4090 is an orally active enterocytic-specific microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 8.0 nM. SLX-4090 can be used for the research of dyslipidemia.
  • HY-177291
    LAB687
    		Inhibitor
    LAB687 (Compound 2a) is a Microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.9  nM for the secretion of apoB from HepG2 cells. LAB687 is also a Smoothened (Smo) antagonist with IC50s of 2.48 and 3.42 μM for mouse and human Smo receptor, respectively. LAB687 can lower the level of triglycerides and LDL cholesterol and inhibits the Hedgehog signaling pathway.
  • HY-14667S1
    Lomitapide-d4
    		Inhibitor
    Lomitapide-d4 (AEGR-733-d4) is deuterium labeled Lomitapide. Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.
  • HY-14667R
    Lomitapide (Standard)
    		Inhibitor
    Lomitapide (Standard) is the analytical standard of Lomitapide. This product is intended for research and analytical applications. Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.
  • HY-119220
    Granotapide
    		Inhibitor
    Granotapide (JTT-130) is an orally active microsomal triglyceride transfer protein (MTP) inhibitor. Granotapide reduces absorption of cholesterol and triglycerides through inhibition of MTP. Granotapide can be used for the research of dyslipidemia.