Liposome

Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.

References:

[1]. Almeida B, Nag OK, Rogers KE, Delehanty JB. Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery. Molecules. 2020;25(23):5672. Published 2020 Dec 1. [Content Brief]

Liposome Related Products (839):

By Effects:	Controls (2) Inhibitor (1) Substrate (1) Modulator (1) Chemicals (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-167012

306Oi9-cis2		99.0%
306Oi9-cis2 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. 306Oi9-cis2 can be used in the preparation of liposomes.

HY-143212

18:0-22:6 DG		99%
18:0-22:6 DG (1-Stearoyl-2-docosahexaenoyl-sn-glycerol) is a diacylglycerol that can bind to RasGRP and modulate MAP kinases activation.

HY-131640

1,2-Didecanoyl PC		98.0%
1,2-Didecanoyl PC (1,2-Didecanoyl-sn-glycero-3-phosphocholine) is a phosphocholine that can be introduced into single-chain mean field theory as a coarse-grained model of saturated phospholipids. The 1,2-Didecanoyl PC model can be used to estimate the free energy of compressive or tensile bilayers in stacks or multilayers and gives a reasonable estimate of the free energy.

HY-W440813

Heptadecan-9-yl 8-bromooctanoate
Heptadecan-9-yl 8-bromooctanoate can be useful for the building or modification of lipid nanoparticles.

HY-172470

DSPE-PEG2000-GE11
DSPE-PEG2000-GE11 is a PEG compound which composed of DSPE and an EGFR targeting peptide (GE11). GE11 can be used for EGFR overexpressed cancer cells. DSPE-PEG2000-GE11 can be used for drug delivery.

HY-N12762

DGTS		99.0%
DGTS, as described, is a structural isomer of DGTA and one of the most common betaine lipids found in microalgae, particularly abundant in Chlorophyceae. DGTS is a helper lipid that is structurally similar to DSPE or DOPE.

HY-144016

16:0 EPC chloride		99.93%
16:0 EPC chloride, a P-O-ethyl derivative, is a saturated cationic lipid. 16:0 EPC chloride can serve as a DNA and RNA transfecting agent. 16:0 EPC chloride can be used as a co-adjuvant for preparing vaccines and promote drug delivery.

HY-W590548

ATX-001		98.0%
ATX-001 is an ionizable cationic lipid. ATX-001 can be used in the formation of lipid nanoparticles (LNPs) for the delivery mRNA.

HY-W343736

1,3-Dipalmitoyl-glycero-2-phosphoethanolamine		99.0%
1,3-Dipalmitoyl-glycero-2-phosphoethanolamine is a phospholipid containing the saturated long-chain (16:0) stearic acid inserted at the sn-1 and sn-3 positions and PE at the sn-2 site. It can be used in the generation of micelles, liposomes, and other types of artificial membranes.

HY-149156

Lipid C24		99.9%
Lipid C24 is a cationic ionizable lipid that can be used for synthesizing lipid nanoparticles. Lipid C24 can be used in the study of drug delivery.

HY-159715

Lipid DIM1		99.0%
Lipid DIM1 is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). Lipid DIM1 is a carrier for both siRNA and mRNA.

HY-170704

DSPE-PEG2000-TCO
DSPE-PEG2000-TCO is a PEGylated derivative of 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (HY-112530) that can be used to construct lipid nanoparticles (LNPs).

HY-167003

L16		99.69%
L16 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. L16 can be used in the preparation of liposomes.

HY-W800776

DORI
DORI is a cationic lipid that can deliver plasmid DNA in vitro. DORI has lower cytotoxicity and high transfection efficiency.

HY-167011

Al-28
Al-28 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. Al-28 can be used in the preparation of liposomes.

HY-145798

N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide		≥98.0%
N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide is an analogue of TT3 (HY-148049). TT3 is an ionizable lipid-like materials for mRNA delivery.

HY-153231A

eGFP mRNA-LNP (500 ng/μL)
eGFP mRNA-LNP (500 ng/μL) is a lipid nanoparticle (LNP) containing eGFP mRNA. eGFP mRNA-LNP carries Enhanced Green Fluorescent Protein (eGFP), which will express green fluorescent protein after entering the cell. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry (excitation wavelength = 488 nm; emission wavelength = 535/40 bandpass). eGFP mRNA-LNP can be used for RNA delivery, translation efficiency and cell viability.

HY-160553

9322-O16B		99.7%
9322-O16B, an ionizable cationic lipid, is used for LNP generation.

HY-144000

DSPE-PEG-PDP ammonium
DSPE-PEG-PDP ammonium is a phospholipid PEG conjugate that can be used in drug delivery applications.

HY-W409806

Cholesterylamine
Cholesterylamine is a cationic lipid. Cholesterylamine can be added to the PLGA to prepare PLGA particle having surface charge. Cholesterylamine can be used for drug delivery. Cholesterylamine can be used for autoimmune diseases and allergy research.

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