Liposome

Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.

References:

[1]. Almeida B, Nag OK, Rogers KE, Delehanty JB. Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery. Molecules. 2020;25(23):5672. Published 2020 Dec 1. [Content Brief]

Liposome Related Products (839):

By Effects:	Controls (2) Inhibitor (1) Substrate (1) Modulator (1) Chemicals (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-147087

YSK 05		98.68%
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo.

HY-159726

C10-200		98.0%
C10-200 is an ionizable cationic lipid that can be used to generate lipid nanoparticles (LNPs). C10-200 is used in the study of mRNA delivery.

HY-128468

1,2-Dimyristoyl-sn-glycerol		99.96%
1,2-Dimyristoyl-sn-glycerol is a saturated diacylglycerol and a weak second messenger for the activation of PKC.

HY-177069

4A3-SC7		98.55%
4A3-SC7 is a polymer of 4A3 amine and is an ionizable lipid component. 4A3-SC7 can be used to prepare lipid nanoparticles (LNPs) to construct a selective organ targeting (SORT) LNP platform.

HY-160705

PNI 132	Chemical
PNI 132, an ionizable lipid derived from the patent WO2020252589A, is useful in the formulation of lipid nanoparticles.

HY-160852

YSK 12C4		98.31%
YSK 12C4 is an ionizable cationic lipid primarily used to enhance siRNA cellular delivery via multifunctional envelope-type nanodevices (MEND). YSK 12C4 promotes siRNA uptake and endosomal escape, effectively silencing genes in human immune cell lines.

HY-118319

MJN228		99.30%
MJN228 is a lipid-binding protein nucleobindin-1 (NUCB1) inhibitor with an IC₅₀ of 3.3 μM.

HY-W591461

DSPE-PEG-COOH, MW 2000		99.95%
DSPE-PEG-COOH, MW 2000 is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. The terminal carboxylic acid can react with primary amine groups to form a stable amide bond.

HY-112523A

DMTAP		99.81%
DMTAP is a cationic lipid that can be used for delivery of DNA, RNAi and drugs.

HY-168399

PEG(2000)-C-DMG		98.0%
PEG(2000)-C-DMG is a PEGylated derivative of 1,2-Dimyristoyl-sn-glycerol (HY-128468). PEG(2000)-C-DMG can be used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of siRNA.

HY-144013H

18:0 mPEG5000 PE ammonium		99%
18:0 mPEG5000 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-172706

DSPE-PEG5000-RVG29
DSPE-PEG5000-RVG29 is a PEG compound which composed of DSPE and a Rabies virus glycoprotein 29 (RVG29). RVG29 can bind specifically to the nicotinic acetylcholine receptor (nAChR) at the blood-brain barrier (BBB) and cross over the BBB.

HY-167545

1-Palmitoyl-2-oleoylphosphatidylethanolamine		99.90%
1-Palmitoyl-2-oleoylphosphatidylethanolamine (POPE) is a PE-based synthetic phospholipid that can intercalate with other amphiphilic molecules to form stable bilayers at physiological pH. 1-Palmitoyl-2-oleoylphosphatidylethanolamine can be used in drug delivery research.

HY-W440927

Stearic acid-PEG-NHS, MW 2000
Stearic acid-PEG-NHS, MW 2,000 is an amphiphatic PEG polymer which forms micelles in an aqueous solution for drug-loaded nanoparticles. The NHS ester is reactive with amine to form a stable amide bond. Reagent grade, for research purpose.

HY-172271

DSPE-PEG1000-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10)
DSPE-PEG1000-LyP-1 is a PEG compound which composed of DSPE and a nine residue peptide (LyP-1) (HY-P2526). LyP-1 targets tumor-associated lymphatic vessels and macrophages.

HY-W441009A

DSPE-PEG-Maleimide (MW 3400) ammonium
DSPE-PEG-Maleimide (MW 3400) ammonium has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-Maleimide (MW 3400) ammonium can be used in drug delivery research.

HY-148702

di-Pal-MTO		98.37%
di-Pal-MTO is a palm oil-based lipid produced by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity.

HY-147072

1-Stearoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine sodium		99.0%
1-Stearoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine sodium is a glycerophospholipid.

HY-144018

18:1 EPC chloride		99.0%
18:1 EPC chloride is a cationic alkylated phospholipid and also an egg yolk phosphatidylcholine. 18:1 EPC chloride can be used in research on liposomes and drug delivery.

HY-156616

VC1052		99.72%
VC1052 is a dialkoxypropylammonium-based material and is the core cationic lipid component of the cationic lipid adjuvant Vaxfectin (HY-142998). Vaxfectin consists of VC1052 and lipid DPyPE (HY-112766) in a 1:1 molar ratio. Vaxfectin can be used as a vaccine adjuvant for the preparation of plasmid DNA and protein vaccines.

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